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Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study

Hepatitis E virus (HEV) is a major cause of viral hepatitis around the world, especially in developing countries. Recently, HEV has also been recognized as important cause of hepatitis in Europe and Japan, however, there is a paucity of clinical data from the United States. The overall seroprevalenc...

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Autores principales: Kmush, Brittany L., Lu, Amelia M., Spillane, Taylor, Hruska, Bryce, Gump, Brooks B., Bendinskas, Kestutis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837474/
https://www.ncbi.nlm.nih.gov/pubmed/33497387
http://dx.doi.org/10.1371/journal.pone.0245850
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author Kmush, Brittany L.
Lu, Amelia M.
Spillane, Taylor
Hruska, Bryce
Gump, Brooks B.
Bendinskas, Kestutis G.
author_facet Kmush, Brittany L.
Lu, Amelia M.
Spillane, Taylor
Hruska, Bryce
Gump, Brooks B.
Bendinskas, Kestutis G.
author_sort Kmush, Brittany L.
collection PubMed
description Hepatitis E virus (HEV) is a major cause of viral hepatitis around the world, especially in developing countries. Recently, HEV has also been recognized as important cause of hepatitis in Europe and Japan, however, there is a paucity of clinical data from the United States. The overall seroprevalence of HEV antibodies is around 10% in the United States, but considerable variation is seen based on geographic location, year, and assay used. In this study, 63 adults and 417 children from New York State were tested for anti-HEV IgG antibodies using the commercially available Wantai IgG assay. The overall seroprevalence of HEV antibodies among adult participants was 9.52% (95% CI: 3.58–19.59%). Positive adults tended to be older than HEV negative adults, all positive adults were female. Only 3 (0.7%, 95% CI:: 0.15–2.09%) of the children were positive, all positive children were male. These results are consistent with global and United States trends in HEV seroprevalence.
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spelling pubmed-78374742021-02-02 Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study Kmush, Brittany L. Lu, Amelia M. Spillane, Taylor Hruska, Bryce Gump, Brooks B. Bendinskas, Kestutis G. PLoS One Research Article Hepatitis E virus (HEV) is a major cause of viral hepatitis around the world, especially in developing countries. Recently, HEV has also been recognized as important cause of hepatitis in Europe and Japan, however, there is a paucity of clinical data from the United States. The overall seroprevalence of HEV antibodies is around 10% in the United States, but considerable variation is seen based on geographic location, year, and assay used. In this study, 63 adults and 417 children from New York State were tested for anti-HEV IgG antibodies using the commercially available Wantai IgG assay. The overall seroprevalence of HEV antibodies among adult participants was 9.52% (95% CI: 3.58–19.59%). Positive adults tended to be older than HEV negative adults, all positive adults were female. Only 3 (0.7%, 95% CI:: 0.15–2.09%) of the children were positive, all positive children were male. These results are consistent with global and United States trends in HEV seroprevalence. Public Library of Science 2021-01-26 /pmc/articles/PMC7837474/ /pubmed/33497387 http://dx.doi.org/10.1371/journal.pone.0245850 Text en © 2021 Kmush et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kmush, Brittany L.
Lu, Amelia M.
Spillane, Taylor
Hruska, Bryce
Gump, Brooks B.
Bendinskas, Kestutis G.
Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title_full Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title_fullStr Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title_full_unstemmed Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title_short Seroprevalence of hepatitis E virus antibodies in adults and children from upstate New York: A cross-sectional study
title_sort seroprevalence of hepatitis e virus antibodies in adults and children from upstate new york: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837474/
https://www.ncbi.nlm.nih.gov/pubmed/33497387
http://dx.doi.org/10.1371/journal.pone.0245850
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