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The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study

BACKGROUND AND AIM: The association between body mass index (BMI) and functional gastrointestinal disorders (FGIDs) has been inconsistent. We aimed to explore the association of BMI with FGIDs in a primary care setting to provide more data in this area. METHODS: A cross-sectional study of consecutiv...

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Autores principales: Beh, Keng Hau, Chuah, Kee Huat, Rappek, Nurul Azmi Mahamad, Mahadeva, Sanjiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837482/
https://www.ncbi.nlm.nih.gov/pubmed/33497382
http://dx.doi.org/10.1371/journal.pone.0245511
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author Beh, Keng Hau
Chuah, Kee Huat
Rappek, Nurul Azmi Mahamad
Mahadeva, Sanjiv
author_facet Beh, Keng Hau
Chuah, Kee Huat
Rappek, Nurul Azmi Mahamad
Mahadeva, Sanjiv
author_sort Beh, Keng Hau
collection PubMed
description BACKGROUND AND AIM: The association between body mass index (BMI) and functional gastrointestinal disorders (FGIDs) has been inconsistent. We aimed to explore the association of BMI with FGIDs in a primary care setting to provide more data in this area. METHODS: A cross-sectional study of consecutive Asian adults attending a primary healthcare setting was conducted. This study was conducted in 2 phases: The association between BMI and common FGIDs (functional diarrhea/FD, irritable bowel syndrome/IBS, functional diarrhea and functional constipation/FC) was studied initially. The influence of anxiety and depression on BMI and FGIDs was additionally explored in phase 2. RESULTS: A total of 1002 subjects (median age 32 years, 65.4% females, 90.7% Malay ethnicity, 73.2% higher than secondary level education) were recruited between August 2019 to January 2020. The majority of subjects were obese (39.2%), and had central obesity (51.7%), while 6.1% had metabolic syndrome. The prevalence of FD, IBS, functional diarrhea and FC were 7.5% (n = 75), 4.0% (n = 40), 1.2% (n = 12) and 10.5% (n = 105) respectively, based on the Rome III criteria. Among individual FGIDs, FD subjects had more underweight adults (BMI<18.5kg/m(2)) compared to controls (13.3% vs 3.5%, P = 0.002) and being underweight remained as an independent association with FD [OR = 3.648 (95%CI 1.494–8.905), P = 0.004] at multi-variate analysis. There were no independent associations between BMI and other FGIDs. When psychological morbidity was additionally explored, anxiety (OR 2.032; 95%CI = 1.034–3.991, p = 0.040), but not depression, and a BMI<18.5kg/m(2) (OR 3.231; 95%CI = 1.066–9.796, p = 0.038) were found to be independently associated with FD. CONCLUSIONS: FD, but not other FGIDs, is associated with being underweight. This association is independent of the presence of anxiety.
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spelling pubmed-78374822021-02-02 The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study Beh, Keng Hau Chuah, Kee Huat Rappek, Nurul Azmi Mahamad Mahadeva, Sanjiv PLoS One Research Article BACKGROUND AND AIM: The association between body mass index (BMI) and functional gastrointestinal disorders (FGIDs) has been inconsistent. We aimed to explore the association of BMI with FGIDs in a primary care setting to provide more data in this area. METHODS: A cross-sectional study of consecutive Asian adults attending a primary healthcare setting was conducted. This study was conducted in 2 phases: The association between BMI and common FGIDs (functional diarrhea/FD, irritable bowel syndrome/IBS, functional diarrhea and functional constipation/FC) was studied initially. The influence of anxiety and depression on BMI and FGIDs was additionally explored in phase 2. RESULTS: A total of 1002 subjects (median age 32 years, 65.4% females, 90.7% Malay ethnicity, 73.2% higher than secondary level education) were recruited between August 2019 to January 2020. The majority of subjects were obese (39.2%), and had central obesity (51.7%), while 6.1% had metabolic syndrome. The prevalence of FD, IBS, functional diarrhea and FC were 7.5% (n = 75), 4.0% (n = 40), 1.2% (n = 12) and 10.5% (n = 105) respectively, based on the Rome III criteria. Among individual FGIDs, FD subjects had more underweight adults (BMI<18.5kg/m(2)) compared to controls (13.3% vs 3.5%, P = 0.002) and being underweight remained as an independent association with FD [OR = 3.648 (95%CI 1.494–8.905), P = 0.004] at multi-variate analysis. There were no independent associations between BMI and other FGIDs. When psychological morbidity was additionally explored, anxiety (OR 2.032; 95%CI = 1.034–3.991, p = 0.040), but not depression, and a BMI<18.5kg/m(2) (OR 3.231; 95%CI = 1.066–9.796, p = 0.038) were found to be independently associated with FD. CONCLUSIONS: FD, but not other FGIDs, is associated with being underweight. This association is independent of the presence of anxiety. Public Library of Science 2021-01-26 /pmc/articles/PMC7837482/ /pubmed/33497382 http://dx.doi.org/10.1371/journal.pone.0245511 Text en © 2021 Beh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Beh, Keng Hau
Chuah, Kee Huat
Rappek, Nurul Azmi Mahamad
Mahadeva, Sanjiv
The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title_full The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title_fullStr The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title_full_unstemmed The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title_short The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study
title_sort association of body mass index with functional dyspepsia is independent of psychological morbidity: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837482/
https://www.ncbi.nlm.nih.gov/pubmed/33497382
http://dx.doi.org/10.1371/journal.pone.0245511
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