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Identification and Targeting of Thomsen–Friedenreich and IL1RAP Antigens on Chronic Myeloid Leukemia Stem Cells Using Bi-Specific Antibodies

INTRODUCTION: Quiescent leukemia stem cells (LSCs) play a major role in therapeutic resistance and disease progression of chronic myeloid leukemia (CML). LSCs belong to the primitive population; CD34+CD38-Lin-, which does not distinguish normal hematopoietic stem cells (HSC) from CML LSCs. Because T...

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Detalles Bibliográficos
Autores principales:	Eldesouki, Raghda E, Wu, Chengxiang, Saleh, Fayez M, Mohammed, Eman Abdel-Moemen, Younes, Soha, Hassan, Naglaa Elsayed, Brown, Theresa C, Alt, Eckhard U, Robinson, James E, Badr, Fouad Mohamed, Braun, Stephen E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837560/ https://www.ncbi.nlm.nih.gov/pubmed/33519209 http://dx.doi.org/10.2147/OTT.S255299

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