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Collateral sensitivity associated with antibiotic resistance plasmids
Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies desig...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837676/ https://www.ncbi.nlm.nih.gov/pubmed/33470194 http://dx.doi.org/10.7554/eLife.65130 |
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author | Herencias, Cristina Rodríguez-Beltrán, Jerónimo León-Sampedro, Ricardo Alonso-del Valle, Aida Palkovičová, Jana Cantón, Rafael San Millán, Álvaro |
author_facet | Herencias, Cristina Rodríguez-Beltrán, Jerónimo León-Sampedro, Ricardo Alonso-del Valle, Aida Palkovičová, Jana Cantón, Rafael San Millán, Álvaro |
author_sort | Herencias, Cristina |
collection | PubMed |
description | Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the clinically important carbapenem-resistance conjugative plasmid pOXA-48. In addition, we describe the conservation of CS in clinical E. coli isolates and its application to selectively kill plasmid-carrying bacteria. Our results provide new insights that establish the basis for developing CS-informed treatment strategies to combat plasmid-mediated ABR. |
format | Online Article Text |
id | pubmed-7837676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78376762021-01-27 Collateral sensitivity associated with antibiotic resistance plasmids Herencias, Cristina Rodríguez-Beltrán, Jerónimo León-Sampedro, Ricardo Alonso-del Valle, Aida Palkovičová, Jana Cantón, Rafael San Millán, Álvaro eLife Evolutionary Biology Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic. Recent studies have focused on CS strategies designed against ABR mediated by chromosomal mutations. However, one of the main drivers of ABR in clinically relevant bacteria is the horizontal transfer of ABR genes mediated by plasmids. Here, we report the first analysis of CS associated with the acquisition of complete ABR plasmids, including the clinically important carbapenem-resistance conjugative plasmid pOXA-48. In addition, we describe the conservation of CS in clinical E. coli isolates and its application to selectively kill plasmid-carrying bacteria. Our results provide new insights that establish the basis for developing CS-informed treatment strategies to combat plasmid-mediated ABR. eLife Sciences Publications, Ltd 2021-01-20 /pmc/articles/PMC7837676/ /pubmed/33470194 http://dx.doi.org/10.7554/eLife.65130 Text en © 2021, Herencias et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Herencias, Cristina Rodríguez-Beltrán, Jerónimo León-Sampedro, Ricardo Alonso-del Valle, Aida Palkovičová, Jana Cantón, Rafael San Millán, Álvaro Collateral sensitivity associated with antibiotic resistance plasmids |
title | Collateral sensitivity associated with antibiotic resistance plasmids |
title_full | Collateral sensitivity associated with antibiotic resistance plasmids |
title_fullStr | Collateral sensitivity associated with antibiotic resistance plasmids |
title_full_unstemmed | Collateral sensitivity associated with antibiotic resistance plasmids |
title_short | Collateral sensitivity associated with antibiotic resistance plasmids |
title_sort | collateral sensitivity associated with antibiotic resistance plasmids |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837676/ https://www.ncbi.nlm.nih.gov/pubmed/33470194 http://dx.doi.org/10.7554/eLife.65130 |
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