NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

Using 3KO (triple NOX [NADPH oxidase] knockout) mice (ie, NOX1(−/−)/NOX2(−/−)/NOX4(−/−)), we aimed to clarify the role of this family of enzymes in the regulation of platelets in vitro and hemostasis in vivo. APPROACH AND RESULTS: 3KO mice displayed significantly reduced platelet superoxide radical...

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Detalles Bibliográficos
Autores principales: Vara, Dina, Mailer, Reiner K., Tarafdar, Anuradha, Wolska, Nina, Heestermans, Marco, Konrath, Sandra, Spaeth, Manuela, Renné, Thomas, Schröder, Katrin, Pula, Giordano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837688/
https://www.ncbi.nlm.nih.gov/pubmed/33267663
http://dx.doi.org/10.1161/ATVBAHA.120.315565

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