Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases

The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures...

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Detalles Bibliográficos
Autores principales: Xu, Xingyun, Miao, Zhigang, Sun, Miao, Wan, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837765/
https://www.ncbi.nlm.nih.gov/pubmed/33532485
http://dx.doi.org/10.1155/2021/6632719
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author Xu, Xingyun
Miao, Zhigang
Sun, Miao
Wan, Bo
author_facet Xu, Xingyun
Miao, Zhigang
Sun, Miao
Wan, Bo
author_sort Xu, Xingyun
collection PubMed
description The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.
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spelling pubmed-78377652021-02-01 Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases Xu, Xingyun Miao, Zhigang Sun, Miao Wan, Bo Int J Genomics Review Article The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved. Hindawi 2021-01-19 /pmc/articles/PMC7837765/ /pubmed/33532485 http://dx.doi.org/10.1155/2021/6632719 Text en Copyright © 2021 Xingyun Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Xingyun
Miao, Zhigang
Sun, Miao
Wan, Bo
Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title_full Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title_fullStr Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title_full_unstemmed Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title_short Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
title_sort epigenetic mechanisms of paternal stress in offspring development and diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837765/
https://www.ncbi.nlm.nih.gov/pubmed/33532485
http://dx.doi.org/10.1155/2021/6632719
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AT sunmiao epigeneticmechanismsofpaternalstressinoffspringdevelopmentanddiseases
AT wanbo epigeneticmechanismsofpaternalstressinoffspringdevelopmentanddiseases

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