Cargando…
Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients
OBJECTIVE: Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has an independent effect on NAFLD in a population of type 2 diabetes remains unknown. The purpose of this study was to identify the pote...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837775/ https://www.ncbi.nlm.nih.gov/pubmed/33532498 http://dx.doi.org/10.1155/2021/8868339 |
_version_ | 1783643019515265024 |
---|---|
author | Shi, Rou Lin, Chunwen Hong, Yaping Xia, Xiaoying Chen, Yingjian Li, Shu Xiu, Liangchang |
author_facet | Shi, Rou Lin, Chunwen Hong, Yaping Xia, Xiaoying Chen, Yingjian Li, Shu Xiu, Liangchang |
author_sort | Shi, Rou |
collection | PubMed |
description | OBJECTIVE: Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has an independent effect on NAFLD in a population of type 2 diabetes remains unknown. The purpose of this study was to identify the potential role of FT3 in NAFLD with T2DM. DESIGN: A cross-sectional study. Patient. A total of 859 T2DM patients who met the inclusion criteria were included. There were 506 T2DM patients without NAFLD and 353 T2DM patients with NAFLD. METHODS: The independent samples t-test or Wilcoxon rank sum test were used for continuous variables of different distribution types, while the chi-square test was used for categorical variables. Pearson correlation analysis and linear regression were used to analyze the correlation between FT3 and clinical measurements and biochemical indicators. Multivariate logistic regression analysis was used to determine independent predictors. RESULTS: Patients with NAFLD had higher BMI, SBP, and DBP, longer duration of T2DM, and higher islet function index, blood glucose index, liver function index, renal function index, blood lipid index, and FT3. We also found that FT3 was affected by other five indicators, including ALT, CR, GGT, TC, and LDL-C only in the NAFLD group but not in the non-NAFLD group. FT3 was significantly associated with NAFLD in T2DM patients, and the prevalence of NAFLD increased gradually from the lowest FT3 tertile to the highest FT3 tertile (P for trend < 0.001). CONCLUSION: FT3 is independently associated with NAFLD in hospitalized T2DM patients after rigorous adjustment for various metabolic parameters. |
format | Online Article Text |
id | pubmed-7837775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78377752021-02-01 Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients Shi, Rou Lin, Chunwen Hong, Yaping Xia, Xiaoying Chen, Yingjian Li, Shu Xiu, Liangchang Biomed Res Int Research Article OBJECTIVE: Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has an independent effect on NAFLD in a population of type 2 diabetes remains unknown. The purpose of this study was to identify the potential role of FT3 in NAFLD with T2DM. DESIGN: A cross-sectional study. Patient. A total of 859 T2DM patients who met the inclusion criteria were included. There were 506 T2DM patients without NAFLD and 353 T2DM patients with NAFLD. METHODS: The independent samples t-test or Wilcoxon rank sum test were used for continuous variables of different distribution types, while the chi-square test was used for categorical variables. Pearson correlation analysis and linear regression were used to analyze the correlation between FT3 and clinical measurements and biochemical indicators. Multivariate logistic regression analysis was used to determine independent predictors. RESULTS: Patients with NAFLD had higher BMI, SBP, and DBP, longer duration of T2DM, and higher islet function index, blood glucose index, liver function index, renal function index, blood lipid index, and FT3. We also found that FT3 was affected by other five indicators, including ALT, CR, GGT, TC, and LDL-C only in the NAFLD group but not in the non-NAFLD group. FT3 was significantly associated with NAFLD in T2DM patients, and the prevalence of NAFLD increased gradually from the lowest FT3 tertile to the highest FT3 tertile (P for trend < 0.001). CONCLUSION: FT3 is independently associated with NAFLD in hospitalized T2DM patients after rigorous adjustment for various metabolic parameters. Hindawi 2021-01-19 /pmc/articles/PMC7837775/ /pubmed/33532498 http://dx.doi.org/10.1155/2021/8868339 Text en Copyright © 2021 Rou Shi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shi, Rou Lin, Chunwen Hong, Yaping Xia, Xiaoying Chen, Yingjian Li, Shu Xiu, Liangchang Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title | Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title_full | Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title_fullStr | Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title_full_unstemmed | Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title_short | Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients |
title_sort | free triiodothyronine is independently associated with nonalcoholic fatty liver disease in hospitalized type 2 diabetes mellitus patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837775/ https://www.ncbi.nlm.nih.gov/pubmed/33532498 http://dx.doi.org/10.1155/2021/8868339 |
work_keys_str_mv | AT shirou freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT linchunwen freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT hongyaping freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT xiaxiaoying freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT chenyingjian freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT lishu freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients AT xiuliangchang freetriiodothyronineisindependentlyassociatedwithnonalcoholicfattyliverdiseaseinhospitalizedtype2diabetesmellituspatients |