Cargando…

Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion

Curcumin (diferuloylmethane) is a major component of turmeric, which is isolated from the rhizomes of Curcuma longa L. from the family Zingiberaceae. It is used as a dietary pigment for curry and in traditional Indian medicine for its anti-inflammatory and attenuating pain effects. This study aimed...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hanwool, Lee, Jong-Hyuk, Sim, Ji Hoon, Park, Jihoon, Choi, Seong-Soo, Leem, Jeong Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837777/
https://www.ncbi.nlm.nih.gov/pubmed/33532012
http://dx.doi.org/10.1155/2021/8787231
_version_ 1783643020284919808
author Park, Hanwool
Lee, Jong-Hyuk
Sim, Ji Hoon
Park, Jihoon
Choi, Seong-Soo
Leem, Jeong Gil
author_facet Park, Hanwool
Lee, Jong-Hyuk
Sim, Ji Hoon
Park, Jihoon
Choi, Seong-Soo
Leem, Jeong Gil
author_sort Park, Hanwool
collection PubMed
description Curcumin (diferuloylmethane) is a major component of turmeric, which is isolated from the rhizomes of Curcuma longa L. from the family Zingiberaceae. It is used as a dietary pigment for curry and in traditional Indian medicine for its anti-inflammatory and attenuating pain effects. This study aimed to evaluate the beneficial effects of curcumin in a rat model of diabetic neuropathic pain. Additionally, we investigated the involvement of the phosphorylated form of c-Jun N-terminal kinase (pJNK) located in the neurons and astrocytes of the dorsal root ganglion (DRG). To induce diabetic neuropathic pain in rats, 50 mg/kg of streptozotocin (STZ) was intraperitoneally injected. After 4 weeks, rats were administered the vehicle, 10 mg/kg/day curcumin, or 50 mg/kg/day curcumin orally for 4 consecutive weeks. One day after the final drug administration, we performed behavioral tests to measure responses of rats to mechanical, heat, cold, and acetone-induced cold stimuli. After behavioral tests, pJNK expression in the DRG was evaluated using western blot assay and immunohistochemistry. Curcumin treatment for 4 consecutive weeks in STZ-induced diabetic neuropathic pain rats improved behavioral responses to mechanical, cold, and thermal stimuli. Increased pJNK expression in the astrocytes and neurons of the DRG in STZ-induced diabetic neuropathic pain rats was reduced by curcumin treatment for 4 consecutive weeks. We suggest that curcumin can be an option for the treatment of diabetes-related neuropathic pain, and one of the mechanisms that underlie the action of curcumin may involve pJNK expression in the astrocytes and neurons of the DRG.
format Online
Article
Text
id pubmed-7837777
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-78377772021-02-01 Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion Park, Hanwool Lee, Jong-Hyuk Sim, Ji Hoon Park, Jihoon Choi, Seong-Soo Leem, Jeong Gil Pain Res Manag Research Article Curcumin (diferuloylmethane) is a major component of turmeric, which is isolated from the rhizomes of Curcuma longa L. from the family Zingiberaceae. It is used as a dietary pigment for curry and in traditional Indian medicine for its anti-inflammatory and attenuating pain effects. This study aimed to evaluate the beneficial effects of curcumin in a rat model of diabetic neuropathic pain. Additionally, we investigated the involvement of the phosphorylated form of c-Jun N-terminal kinase (pJNK) located in the neurons and astrocytes of the dorsal root ganglion (DRG). To induce diabetic neuropathic pain in rats, 50 mg/kg of streptozotocin (STZ) was intraperitoneally injected. After 4 weeks, rats were administered the vehicle, 10 mg/kg/day curcumin, or 50 mg/kg/day curcumin orally for 4 consecutive weeks. One day after the final drug administration, we performed behavioral tests to measure responses of rats to mechanical, heat, cold, and acetone-induced cold stimuli. After behavioral tests, pJNK expression in the DRG was evaluated using western blot assay and immunohistochemistry. Curcumin treatment for 4 consecutive weeks in STZ-induced diabetic neuropathic pain rats improved behavioral responses to mechanical, cold, and thermal stimuli. Increased pJNK expression in the astrocytes and neurons of the DRG in STZ-induced diabetic neuropathic pain rats was reduced by curcumin treatment for 4 consecutive weeks. We suggest that curcumin can be an option for the treatment of diabetes-related neuropathic pain, and one of the mechanisms that underlie the action of curcumin may involve pJNK expression in the astrocytes and neurons of the DRG. Hindawi 2021-01-19 /pmc/articles/PMC7837777/ /pubmed/33532012 http://dx.doi.org/10.1155/2021/8787231 Text en Copyright © 2021 Hanwool Park et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Park, Hanwool
Lee, Jong-Hyuk
Sim, Ji Hoon
Park, Jihoon
Choi, Seong-Soo
Leem, Jeong Gil
Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title_full Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title_fullStr Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title_full_unstemmed Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title_short Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
title_sort effects of curcumin treatment in a diabetic neuropathic pain model of rats: involvement of c-jun n-terminal kinase located in the astrocytes and neurons of the dorsal root ganglion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837777/
https://www.ncbi.nlm.nih.gov/pubmed/33532012
http://dx.doi.org/10.1155/2021/8787231
work_keys_str_mv AT parkhanwool effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion
AT leejonghyuk effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion
AT simjihoon effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion
AT parkjihoon effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion
AT choiseongsoo effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion
AT leemjeonggil effectsofcurcumintreatmentinadiabeticneuropathicpainmodelofratsinvolvementofcjunnterminalkinaselocatedintheastrocytesandneuronsofthedorsalrootganglion