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Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis
INTRODUCTION: Proliferative vitreous retinopathy (PVR) is characterized by proliferation of cells and contraction of membranes on either the retinal surface or in the vitreous cavity, which leads to retinal detachment and visual impairment. PVR is commonly seen in patients with rhegmatogenous retina...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837824/ https://www.ncbi.nlm.nih.gov/pubmed/33546086 http://dx.doi.org/10.1097/MD.0000000000024412 |
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author | Huang, Hui Lei, Ruxue Li, Yuanyuan Huang, Qun Gao, Na Zou, Weiwen |
author_facet | Huang, Hui Lei, Ruxue Li, Yuanyuan Huang, Qun Gao, Na Zou, Weiwen |
author_sort | Huang, Hui |
collection | PubMed |
description | INTRODUCTION: Proliferative vitreous retinopathy (PVR) is characterized by proliferation of cells and contraction of membranes on either the retinal surface or in the vitreous cavity, which leads to retinal detachment and visual impairment. PVR is commonly seen in patients with rhegmatogenous retinal detachment and diabetic retinopathy, which seriously affects the patient's work and life. Previous studies indicated that Hirudo (Leech) or compound prescription containing Hirudo (Leech) for treatment of PVR would be effective. However, due to the lack of evidence, there are no specific methods or suggestions, so it is necessary to carry out systematic evaluations on Hirudo (Leech) for PVR and provide effective evidence for further research. METHODS AND ANALYSIS: The following 8 databases will be searched: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database, and Wanfang Database. All randomized controlled trials in English or Chinese related to Hirudo (Leech) for PVR will be included. Outcomes will include change in Vitreous opacity, Vision changes, production of the anterior macular membrane, and retinal detachment again. The incidence of adverse events will be assessed for safety evaluation. Study inclusion, data extraction and quality assessment will be performed independently by 2 reviewers. Assessment of risk of bias and data synthesis will be performed using Review Manager V.5.3. RESULTS: In this systematic review and meta-analysis, we will synthesize the studies to assess the safety and efficacy of Hirudo (Leech) for PVR. CONCLUSION: The summary of our study will clarify whether Hirudo (Leech) therapy could be an efficient and safe method for PVR, which can further guide the promotion and application of it. OPEN SCIENCE FRAMEWORK (OSF) REGISTRATION NUMBER: 10.17605/OSF.IO/FP7VG (https://osf.io/fp7vg) |
format | Online Article Text |
id | pubmed-7837824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78378242021-01-27 Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis Huang, Hui Lei, Ruxue Li, Yuanyuan Huang, Qun Gao, Na Zou, Weiwen Medicine (Baltimore) 5800 INTRODUCTION: Proliferative vitreous retinopathy (PVR) is characterized by proliferation of cells and contraction of membranes on either the retinal surface or in the vitreous cavity, which leads to retinal detachment and visual impairment. PVR is commonly seen in patients with rhegmatogenous retinal detachment and diabetic retinopathy, which seriously affects the patient's work and life. Previous studies indicated that Hirudo (Leech) or compound prescription containing Hirudo (Leech) for treatment of PVR would be effective. However, due to the lack of evidence, there are no specific methods or suggestions, so it is necessary to carry out systematic evaluations on Hirudo (Leech) for PVR and provide effective evidence for further research. METHODS AND ANALYSIS: The following 8 databases will be searched: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database, and Wanfang Database. All randomized controlled trials in English or Chinese related to Hirudo (Leech) for PVR will be included. Outcomes will include change in Vitreous opacity, Vision changes, production of the anterior macular membrane, and retinal detachment again. The incidence of adverse events will be assessed for safety evaluation. Study inclusion, data extraction and quality assessment will be performed independently by 2 reviewers. Assessment of risk of bias and data synthesis will be performed using Review Manager V.5.3. RESULTS: In this systematic review and meta-analysis, we will synthesize the studies to assess the safety and efficacy of Hirudo (Leech) for PVR. CONCLUSION: The summary of our study will clarify whether Hirudo (Leech) therapy could be an efficient and safe method for PVR, which can further guide the promotion and application of it. OPEN SCIENCE FRAMEWORK (OSF) REGISTRATION NUMBER: 10.17605/OSF.IO/FP7VG (https://osf.io/fp7vg) Lippincott Williams & Wilkins 2021-01-22 /pmc/articles/PMC7837824/ /pubmed/33546086 http://dx.doi.org/10.1097/MD.0000000000024412 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5800 Huang, Hui Lei, Ruxue Li, Yuanyuan Huang, Qun Gao, Na Zou, Weiwen Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title | Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title_full | Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title_fullStr | Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title_full_unstemmed | Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title_short | Hirudo (Leech) for proliferative vitreous retinopathy: A protocol for systemic review and meta-analysis |
title_sort | hirudo (leech) for proliferative vitreous retinopathy: a protocol for systemic review and meta-analysis |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837824/ https://www.ncbi.nlm.nih.gov/pubmed/33546086 http://dx.doi.org/10.1097/MD.0000000000024412 |
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