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Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study

High polyunsaturated fatty acids (PUFAs) intake is recommended for primary and secondary prevention of cardiovascular disease (CVD). However, the association of PUFAs with blood pressure (BP) is still controversial. In the present study, two-sample Mendelian randomization (MR) analysis was performed...

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Autores principales: Ma, Menghuai, Yang, Fangkun, Wang, Zhuo, Bao, Qinyi, Shen, Jinlian, Xie, Xiaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837969/
https://www.ncbi.nlm.nih.gov/pubmed/33546071
http://dx.doi.org/10.1097/MD.0000000000024359
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author Ma, Menghuai
Yang, Fangkun
Wang, Zhuo
Bao, Qinyi
Shen, Jinlian
Xie, Xiaojie
author_facet Ma, Menghuai
Yang, Fangkun
Wang, Zhuo
Bao, Qinyi
Shen, Jinlian
Xie, Xiaojie
author_sort Ma, Menghuai
collection PubMed
description High polyunsaturated fatty acids (PUFAs) intake is recommended for primary and secondary prevention of cardiovascular disease (CVD). However, the association of PUFAs with blood pressure (BP) is still controversial. In the present study, two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship of PUFAs with BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP). Genetic instruments and summary statistics for two-sample MR analysis were obtained from 3 large-scale genome-wide association studies (GWASs). Eight single nucleotide polymorphisms (SNPs) significantly (P < 5 × 10(−8)) related to 6 PUFAs were used as instrumental variables. Conventional inverse-variance weighted method was adopted to evaluate the causality of PUFAs with BP; the Weighted Median, MR-egger, and Leave-one-out method were used for sensitivity analyses. As a result, there was no evidence of a causal association between all PUFAs and SBP. In addition, arachidonic acid (AA, β = −0.04, P < .001) and eicosapentaenoic acid (EPA, β = −0.47, P = .02) were negatively associated with DBP, while linoleic acid (LA, β = 0.03, P = .005) and α-linolenic acid (ALA, β = 3.83, P < .001) were positively associated with DBP. There was no evidence of a causal relationship between either docosapentaenoic acid (DPA) or docosahexaenoic acid (DHA) with DBP. In conclusion, a genetic predisposition to plasma polyunsaturated fatty acid (PUFA) had a divergent effect on DBP, independent of SBP. It suggested that it is helpful for lower DBP level to supplemental intake of AA and EPA or promote the conversion of LA and ALA to AA and EPA respectively, which need to be further validated with randomized controlled studies.
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spelling pubmed-78379692021-01-27 Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study Ma, Menghuai Yang, Fangkun Wang, Zhuo Bao, Qinyi Shen, Jinlian Xie, Xiaojie Medicine (Baltimore) 3400 High polyunsaturated fatty acids (PUFAs) intake is recommended for primary and secondary prevention of cardiovascular disease (CVD). However, the association of PUFAs with blood pressure (BP) is still controversial. In the present study, two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship of PUFAs with BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP). Genetic instruments and summary statistics for two-sample MR analysis were obtained from 3 large-scale genome-wide association studies (GWASs). Eight single nucleotide polymorphisms (SNPs) significantly (P < 5 × 10(−8)) related to 6 PUFAs were used as instrumental variables. Conventional inverse-variance weighted method was adopted to evaluate the causality of PUFAs with BP; the Weighted Median, MR-egger, and Leave-one-out method were used for sensitivity analyses. As a result, there was no evidence of a causal association between all PUFAs and SBP. In addition, arachidonic acid (AA, β = −0.04, P < .001) and eicosapentaenoic acid (EPA, β = −0.47, P = .02) were negatively associated with DBP, while linoleic acid (LA, β = 0.03, P = .005) and α-linolenic acid (ALA, β = 3.83, P < .001) were positively associated with DBP. There was no evidence of a causal relationship between either docosapentaenoic acid (DPA) or docosahexaenoic acid (DHA) with DBP. In conclusion, a genetic predisposition to plasma polyunsaturated fatty acid (PUFA) had a divergent effect on DBP, independent of SBP. It suggested that it is helpful for lower DBP level to supplemental intake of AA and EPA or promote the conversion of LA and ALA to AA and EPA respectively, which need to be further validated with randomized controlled studies. Lippincott Williams & Wilkins 2021-01-22 /pmc/articles/PMC7837969/ /pubmed/33546071 http://dx.doi.org/10.1097/MD.0000000000024359 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3400
Ma, Menghuai
Yang, Fangkun
Wang, Zhuo
Bao, Qinyi
Shen, Jinlian
Xie, Xiaojie
Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title_full Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title_fullStr Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title_full_unstemmed Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title_short Association of plasma polyunsaturated fatty acids with arterial blood pressure: A Mendelian randomization study
title_sort association of plasma polyunsaturated fatty acids with arterial blood pressure: a mendelian randomization study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837969/
https://www.ncbi.nlm.nih.gov/pubmed/33546071
http://dx.doi.org/10.1097/MD.0000000000024359
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