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Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I

Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI). NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits. Dihydrotanshinone-I (DT) is an active component in Salvia miltiorrhiza with NRF2 induction potency. This study seeks to valid...

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Detalles Bibliográficos
Autores principales:	Zeng, Hao, Wang, Lingling, Zhang, Jiawei, Pan, Ting, Yu, Yinghua, Lu, Jingxia, Zhou, Ping, Yang, Hua, Li, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838031/ https://www.ncbi.nlm.nih.gov/pubmed/33532181 http://dx.doi.org/10.1016/j.apsb.2020.09.006

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