Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series o...

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Detalles Bibliográficos
Autores principales: Chang, Xiaosa, Sun, Dejuan, Shi, Danfeng, Wang, Guan, Chen, Yanmei, Zhang, Kai, Tan, Huidan, Liu, Jie, Liu, Bo, Ouyang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838034/
https://www.ncbi.nlm.nih.gov/pubmed/33532187
http://dx.doi.org/10.1016/j.apsb.2020.06.003

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