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Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive “superbug”, and no promising NDM-1 inhibitors were used in clinical practice...

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Detalles Bibliográficos
Autores principales:	Zhao, Bing, Zhang, Xinhui, Yu, Tingting, Liu, Ying, Zhang, Xiaoling, Yao, Yongfang, Feng, Xuejian, Liu, Hongmin, Yu, Dequan, Ma, Liying, Qin, Shangshang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838035/ https://www.ncbi.nlm.nih.gov/pubmed/33532189 http://dx.doi.org/10.1016/j.apsb.2020.07.005

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