Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The benefic...

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Autores principales: Gava, Fabio N., da Silva, Alexandre A., Dai, Xuemei, Harmancey, Romain, Ashraf, Sadia, Omoto, Ana C.M., Salgado, Mateus C., Moak, Sydney P., Li, Xuan, Hall, John E., do Carmo, Jussara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838051/
https://www.ncbi.nlm.nih.gov/pubmed/33532666
http://dx.doi.org/10.1016/j.jacbts.2020.11.007
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author Gava, Fabio N.
da Silva, Alexandre A.
Dai, Xuemei
Harmancey, Romain
Ashraf, Sadia
Omoto, Ana C.M.
Salgado, Mateus C.
Moak, Sydney P.
Li, Xuan
Hall, John E.
do Carmo, Jussara M.
author_facet Gava, Fabio N.
da Silva, Alexandre A.
Dai, Xuemei
Harmancey, Romain
Ashraf, Sadia
Omoto, Ana C.M.
Salgado, Mateus C.
Moak, Sydney P.
Li, Xuan
Hall, John E.
do Carmo, Jussara M.
author_sort Gava, Fabio N.
collection PubMed
description Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca(2+) coupling, and mitochondrial efficiency. These findings highlight a potentially novel therapeutic approach for myocardial infarction and heart failure.
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spelling pubmed-78380512021-02-01 Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System Gava, Fabio N. da Silva, Alexandre A. Dai, Xuemei Harmancey, Romain Ashraf, Sadia Omoto, Ana C.M. Salgado, Mateus C. Moak, Sydney P. Li, Xuan Hall, John E. do Carmo, Jussara M. JACC Basic Transl Sci Preclinical Research Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca(2+) coupling, and mitochondrial efficiency. These findings highlight a potentially novel therapeutic approach for myocardial infarction and heart failure. Elsevier 2021-01-25 /pmc/articles/PMC7838051/ /pubmed/33532666 http://dx.doi.org/10.1016/j.jacbts.2020.11.007 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Gava, Fabio N.
da Silva, Alexandre A.
Dai, Xuemei
Harmancey, Romain
Ashraf, Sadia
Omoto, Ana C.M.
Salgado, Mateus C.
Moak, Sydney P.
Li, Xuan
Hall, John E.
do Carmo, Jussara M.
Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title_full Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title_fullStr Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title_full_unstemmed Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title_short Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System
title_sort restoration of cardiac function after myocardial infarction by long-term activation of the cns leptin-melanocortin system
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838051/
https://www.ncbi.nlm.nih.gov/pubmed/33532666
http://dx.doi.org/10.1016/j.jacbts.2020.11.007
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