Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female se...

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Detalles Bibliográficos
Autores principales: Lau, Emily S., Liu, Elizabeth, Paniagua, Samantha M., Sarma, Amy A., Zampierollo, Giovanna, López, Begoña, Díez, Javier, Wang, Thomas J., Ho, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838053/
https://www.ncbi.nlm.nih.gov/pubmed/33532663
http://dx.doi.org/10.1016/j.jacbts.2020.10.006
Descripción
Sumario:We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.

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