Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female se...

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Detalles Bibliográficos
Autores principales: Lau, Emily S., Liu, Elizabeth, Paniagua, Samantha M., Sarma, Amy A., Zampierollo, Giovanna, López, Begoña, Díez, Javier, Wang, Thomas J., Ho, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838053/
https://www.ncbi.nlm.nih.gov/pubmed/33532663
http://dx.doi.org/10.1016/j.jacbts.2020.10.006
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author Lau, Emily S.
Liu, Elizabeth
Paniagua, Samantha M.
Sarma, Amy A.
Zampierollo, Giovanna
López, Begoña
Díez, Javier
Wang, Thomas J.
Ho, Jennifer E.
author_facet Lau, Emily S.
Liu, Elizabeth
Paniagua, Samantha M.
Sarma, Amy A.
Zampierollo, Giovanna
López, Begoña
Díez, Javier
Wang, Thomas J.
Ho, Jennifer E.
author_sort Lau, Emily S.
collection PubMed
description We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.
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spelling pubmed-78380532021-02-01 Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension Lau, Emily S. Liu, Elizabeth Paniagua, Samantha M. Sarma, Amy A. Zampierollo, Giovanna López, Begoña Díez, Javier Wang, Thomas J. Ho, Jennifer E. JACC Basic Transl Sci Clinical Research We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation. Elsevier 2021-01-06 /pmc/articles/PMC7838053/ /pubmed/33532663 http://dx.doi.org/10.1016/j.jacbts.2020.10.006 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Lau, Emily S.
Liu, Elizabeth
Paniagua, Samantha M.
Sarma, Amy A.
Zampierollo, Giovanna
López, Begoña
Díez, Javier
Wang, Thomas J.
Ho, Jennifer E.
Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title_full Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title_fullStr Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title_full_unstemmed Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title_short Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension
title_sort galectin-3 inhibition with modified citrus pectin in hypertension
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838053/
https://www.ncbi.nlm.nih.gov/pubmed/33532663
http://dx.doi.org/10.1016/j.jacbts.2020.10.006
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