Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis

This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and...

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Autores principales: Bouchareb, Rihab, Guauque-Olarte, Sandra, Snider, Justin, Zaminski, Devyn, Anyanwu, Anelechi, Stelzer, Paul, Lebeche, Djamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838057/
https://www.ncbi.nlm.nih.gov/pubmed/33532664
http://dx.doi.org/10.1016/j.jacbts.2020.11.008
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author Bouchareb, Rihab
Guauque-Olarte, Sandra
Snider, Justin
Zaminski, Devyn
Anyanwu, Anelechi
Stelzer, Paul
Lebeche, Djamel
author_facet Bouchareb, Rihab
Guauque-Olarte, Sandra
Snider, Justin
Zaminski, Devyn
Anyanwu, Anelechi
Stelzer, Paul
Lebeche, Djamel
author_sort Bouchareb, Rihab
collection PubMed
description This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.
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spelling pubmed-78380572021-02-01 Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis Bouchareb, Rihab Guauque-Olarte, Sandra Snider, Justin Zaminski, Devyn Anyanwu, Anelechi Stelzer, Paul Lebeche, Djamel JACC Basic Transl Sci Clinical Research This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis. Elsevier 2021-01-13 /pmc/articles/PMC7838057/ /pubmed/33532664 http://dx.doi.org/10.1016/j.jacbts.2020.11.008 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Bouchareb, Rihab
Guauque-Olarte, Sandra
Snider, Justin
Zaminski, Devyn
Anyanwu, Anelechi
Stelzer, Paul
Lebeche, Djamel
Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title_full Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title_fullStr Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title_full_unstemmed Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title_short Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis
title_sort proteomic architecture of valvular extracellular matrix: fndc1 and mxra5 are new biomarkers of aortic stenosis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838057/
https://www.ncbi.nlm.nih.gov/pubmed/33532664
http://dx.doi.org/10.1016/j.jacbts.2020.11.008
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