Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding

In our previous genome-wide association study, we demonstrated the association between MHC class I-related chain A (MICA) and hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. Increasing membrane-bound MICA (mMICA) in cancer cells by reducing MICA sheddases facilitates...

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Detalles Bibliográficos
Autores principales: Arai, Jun, Goto, Kaku, Otoyama, Yumi, Nakajima, Yoko, Sugiura, Ikuya, Kajiwara, Atsushi, Tojo, Masayuki, Ichikawa, Yuki, Uozumi, Shojiro, Shimozuma, Yuu, Uchikoshi, Manabu, Sakaki, Masashi, Nozawa, Hisako, Nakagawa, Ryo, Muroyama, Ryosuke, Kato, Naoya, Yoshida, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838147/
https://www.ncbi.nlm.nih.gov/pubmed/32683508
http://dx.doi.org/10.1007/s00262-020-02660-2

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