In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals

Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) alleviated fibrosis by stably silencing the AREG gene, and reduced the side effects of conventional siRNA t...

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Detalles Bibliográficos
Autores principales: Son, Seung Seob, Hwang, Soohyun, Park, Jun Hong, Ko, Youngho, Yun, Sung-Il, Lee, Ji-Hye, Son, Beomseok, Kim, Tae Rim, Park, Han-Oh, Lee, Eun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838194/
https://www.ncbi.nlm.nih.gov/pubmed/33500443
http://dx.doi.org/10.1038/s41598-021-81726-2

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