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Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeut...

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Autores principales: Rackayová, Veronika, Flatt, Emmanuelle, Braissant, Olivier, Grosse, Jocelyn, Capobianco, Daniela, Mastromarino, Paola, McMillin, Matthew, DeMorrow, Sharon, McLin, Valérie A., Cudalbu, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838316/
https://www.ncbi.nlm.nih.gov/pubmed/33500487
http://dx.doi.org/10.1038/s41598-021-81871-8
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author Rackayová, Veronika
Flatt, Emmanuelle
Braissant, Olivier
Grosse, Jocelyn
Capobianco, Daniela
Mastromarino, Paola
McMillin, Matthew
DeMorrow, Sharon
McLin, Valérie A.
Cudalbu, Cristina
author_facet Rackayová, Veronika
Flatt, Emmanuelle
Braissant, Olivier
Grosse, Jocelyn
Capobianco, Daniela
Mastromarino, Paola
McMillin, Matthew
DeMorrow, Sharon
McLin, Valérie A.
Cudalbu, Cristina
author_sort Rackayová, Veronika
collection PubMed
description Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo (1)H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients.
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spelling pubmed-78383162021-01-28 Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease Rackayová, Veronika Flatt, Emmanuelle Braissant, Olivier Grosse, Jocelyn Capobianco, Daniela Mastromarino, Paola McMillin, Matthew DeMorrow, Sharon McLin, Valérie A. Cudalbu, Cristina Sci Rep Article Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora using probiotics is emerging as a therapeutic alternative. However, knowledge about how probiotics influence brain metabolite changes during HE is missing. In the present study, we combined the advantages of ultra-high field in vivo (1)H MRS with behavioural tests to analyse whether a long-term treatment with a multistrain probiotic mixture (VIVOMIXX) in a rat model of type C HE had a positive effect on behaviour and neurometabolic changes. We showed that the prophylactic administration of this probiotic formulation led to an increase in gut Bifidobacteria and attenuated changes in locomotor activity and neurometabolic profile in a rat model of type C HE. Both the performance in behavioural tests and the neurometabolic profile of BDL + probiotic rats were improved compared to the BDL group at week 8 post-BDL. They displayed a significantly lesser increase in brain Gln, a milder decrease in brain mIns and a smaller decrease in neurotransmitter Glu than untreated animals. The clinical implications of these findings are potentially far-reaching given that probiotics are generally safe and well-tolerated by patients. Nature Publishing Group UK 2021-01-26 /pmc/articles/PMC7838316/ /pubmed/33500487 http://dx.doi.org/10.1038/s41598-021-81871-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rackayová, Veronika
Flatt, Emmanuelle
Braissant, Olivier
Grosse, Jocelyn
Capobianco, Daniela
Mastromarino, Paola
McMillin, Matthew
DeMorrow, Sharon
McLin, Valérie A.
Cudalbu, Cristina
Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_full Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_fullStr Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_full_unstemmed Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_short Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
title_sort probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838316/
https://www.ncbi.nlm.nih.gov/pubmed/33500487
http://dx.doi.org/10.1038/s41598-021-81871-8
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