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Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth

Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in...

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Autores principales: van den Heuvel, Marion I., Hect, Jasmine L., Smarr, Benjamin L., Qawasmeh, Tamara, Kriegsfeld, Lance J., Barcelona, Jeanne, Hijazi, Kowsar E., Thomason, Moriah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838320/
https://www.ncbi.nlm.nih.gov/pubmed/33500446
http://dx.doi.org/10.1038/s41598-021-81681-y
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author van den Heuvel, Marion I.
Hect, Jasmine L.
Smarr, Benjamin L.
Qawasmeh, Tamara
Kriegsfeld, Lance J.
Barcelona, Jeanne
Hijazi, Kowsar E.
Thomason, Moriah E.
author_facet van den Heuvel, Marion I.
Hect, Jasmine L.
Smarr, Benjamin L.
Qawasmeh, Tamara
Kriegsfeld, Lance J.
Barcelona, Jeanne
Hijazi, Kowsar E.
Thomason, Moriah E.
author_sort van den Heuvel, Marion I.
collection PubMed
description Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas.
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spelling pubmed-78383202021-01-28 Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth van den Heuvel, Marion I. Hect, Jasmine L. Smarr, Benjamin L. Qawasmeh, Tamara Kriegsfeld, Lance J. Barcelona, Jeanne Hijazi, Kowsar E. Thomason, Moriah E. Sci Rep Article Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas. Nature Publishing Group UK 2021-01-26 /pmc/articles/PMC7838320/ /pubmed/33500446 http://dx.doi.org/10.1038/s41598-021-81681-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
van den Heuvel, Marion I.
Hect, Jasmine L.
Smarr, Benjamin L.
Qawasmeh, Tamara
Kriegsfeld, Lance J.
Barcelona, Jeanne
Hijazi, Kowsar E.
Thomason, Moriah E.
Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_full Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_fullStr Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_full_unstemmed Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_short Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_sort maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838320/
https://www.ncbi.nlm.nih.gov/pubmed/33500446
http://dx.doi.org/10.1038/s41598-021-81681-y
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