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Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838320/ https://www.ncbi.nlm.nih.gov/pubmed/33500446 http://dx.doi.org/10.1038/s41598-021-81681-y |
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author | van den Heuvel, Marion I. Hect, Jasmine L. Smarr, Benjamin L. Qawasmeh, Tamara Kriegsfeld, Lance J. Barcelona, Jeanne Hijazi, Kowsar E. Thomason, Moriah E. |
author_facet | van den Heuvel, Marion I. Hect, Jasmine L. Smarr, Benjamin L. Qawasmeh, Tamara Kriegsfeld, Lance J. Barcelona, Jeanne Hijazi, Kowsar E. Thomason, Moriah E. |
author_sort | van den Heuvel, Marion I. |
collection | PubMed |
description | Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas. |
format | Online Article Text |
id | pubmed-7838320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78383202021-01-28 Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth van den Heuvel, Marion I. Hect, Jasmine L. Smarr, Benjamin L. Qawasmeh, Tamara Kriegsfeld, Lance J. Barcelona, Jeanne Hijazi, Kowsar E. Thomason, Moriah E. Sci Rep Article Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas. Nature Publishing Group UK 2021-01-26 /pmc/articles/PMC7838320/ /pubmed/33500446 http://dx.doi.org/10.1038/s41598-021-81681-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article van den Heuvel, Marion I. Hect, Jasmine L. Smarr, Benjamin L. Qawasmeh, Tamara Kriegsfeld, Lance J. Barcelona, Jeanne Hijazi, Kowsar E. Thomason, Moriah E. Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title | Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title_full | Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title_fullStr | Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title_full_unstemmed | Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title_short | Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
title_sort | maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838320/ https://www.ncbi.nlm.nih.gov/pubmed/33500446 http://dx.doi.org/10.1038/s41598-021-81681-y |
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