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Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression
Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838359/ https://www.ncbi.nlm.nih.gov/pubmed/33519557 http://dx.doi.org/10.3389/fpsyt.2020.616501 |
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author | Wang, Zhiyan Cai, Xiaodong Qiu, Rirang Yao, Chen Tian, Ye Gong, Chen Zhang, Yingli Xu, Bin Zhang, Doudou Zang, Yu Liu, Jiali Peng, Bo Li, Luming |
author_facet | Wang, Zhiyan Cai, Xiaodong Qiu, Rirang Yao, Chen Tian, Ye Gong, Chen Zhang, Yingli Xu, Bin Zhang, Doudou Zang, Yu Liu, Jiali Peng, Bo Li, Luming |
author_sort | Wang, Zhiyan |
collection | PubMed |
description | Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral habenula (LHb) DBS for a TRD patient who had failed medical, psychological, electroconvulsive, and ketamine therapy. The DBS system is compatible with 3T magnetic resonance imaging along with local field potential (LFP) streaming. Two DBS electrodes were implanted at the bilateral LHb without any complication. The patient showed acute stimulation effects and achieved long-term improvements in his depression, anxiety, and sleep with left LHb 160 Hz frequency stimulation, accompanying the change of LFPs. These results provided clinical evidence toward the safety and efficacy and electrophysiological basis of LHb DBS for TRD. |
format | Online Article Text |
id | pubmed-7838359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78383592021-01-28 Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression Wang, Zhiyan Cai, Xiaodong Qiu, Rirang Yao, Chen Tian, Ye Gong, Chen Zhang, Yingli Xu, Bin Zhang, Doudou Zang, Yu Liu, Jiali Peng, Bo Li, Luming Front Psychiatry Psychiatry Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral habenula (LHb) DBS for a TRD patient who had failed medical, psychological, electroconvulsive, and ketamine therapy. The DBS system is compatible with 3T magnetic resonance imaging along with local field potential (LFP) streaming. Two DBS electrodes were implanted at the bilateral LHb without any complication. The patient showed acute stimulation effects and achieved long-term improvements in his depression, anxiety, and sleep with left LHb 160 Hz frequency stimulation, accompanying the change of LFPs. These results provided clinical evidence toward the safety and efficacy and electrophysiological basis of LHb DBS for TRD. Frontiers Media S.A. 2021-01-13 /pmc/articles/PMC7838359/ /pubmed/33519557 http://dx.doi.org/10.3389/fpsyt.2020.616501 Text en Copyright © 2021 Wang, Cai, Qiu, Yao, Tian, Gong, Zhang, Xu, Zhang, Zang, Liu, Peng and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Wang, Zhiyan Cai, Xiaodong Qiu, Rirang Yao, Chen Tian, Ye Gong, Chen Zhang, Yingli Xu, Bin Zhang, Doudou Zang, Yu Liu, Jiali Peng, Bo Li, Luming Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title | Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title_full | Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title_fullStr | Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title_full_unstemmed | Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title_short | Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression |
title_sort | case report: lateral habenula deep brain stimulation for treatment-resistant depression |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838359/ https://www.ncbi.nlm.nih.gov/pubmed/33519557 http://dx.doi.org/10.3389/fpsyt.2020.616501 |
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