Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes

Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign ce...

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Autores principales: Kamm, J. Lacy, Riley, Christopher B., Parlane, Natalie, Gee, Erica K, McIlwraith, C. Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838369/
https://www.ncbi.nlm.nih.gov/pubmed/33521090
http://dx.doi.org/10.3389/fvets.2020.617647
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author Kamm, J. Lacy
Riley, Christopher B.
Parlane, Natalie
Gee, Erica K
McIlwraith, C. Wayne
author_facet Kamm, J. Lacy
Riley, Christopher B.
Parlane, Natalie
Gee, Erica K
McIlwraith, C. Wayne
author_sort Kamm, J. Lacy
collection PubMed
description Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments.
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spelling pubmed-78383692021-01-28 Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes Kamm, J. Lacy Riley, Christopher B. Parlane, Natalie Gee, Erica K McIlwraith, C. Wayne Front Vet Sci Veterinary Science Despite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments. Frontiers Media S.A. 2021-01-13 /pmc/articles/PMC7838369/ /pubmed/33521090 http://dx.doi.org/10.3389/fvets.2020.617647 Text en Copyright © 2021 Kamm, Riley, Parlane, Gee and McIlwraith. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kamm, J. Lacy
Riley, Christopher B.
Parlane, Natalie
Gee, Erica K
McIlwraith, C. Wayne
Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title_full Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title_fullStr Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title_full_unstemmed Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title_short Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
title_sort interactions between allogeneic mesenchymal stromal cells and the recipient immune system: a comparative review with relevance to equine outcomes
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838369/
https://www.ncbi.nlm.nih.gov/pubmed/33521090
http://dx.doi.org/10.3389/fvets.2020.617647
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