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Extrinsic Factors Regulating Dendritic Patterning
Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic inte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838386/ https://www.ncbi.nlm.nih.gov/pubmed/33519386 http://dx.doi.org/10.3389/fncel.2020.622808 |
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author | Lin, Tzu-Yang Chen, Pei-Ju Yu, Hung-Hsiang Hsu, Chao-Ping Lee, Chi-Hon |
author_facet | Lin, Tzu-Yang Chen, Pei-Ju Yu, Hung-Hsiang Hsu, Chao-Ping Lee, Chi-Hon |
author_sort | Lin, Tzu-Yang |
collection | PubMed |
description | Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning. Surrounding neurons or supporting cells express adhesion receptors and secreted proteins that respectively, act via direct contact or over short distances to shape, size, and localize dendrites during specific developmental stages. The different ligand-receptor interactions and downstream signaling events appear to direct dendrite morphogenesis by converging on two categorical mechanisms: local cytoskeletal and adhesion modulation and global transcriptional regulation of key dendritic growth components, such as lipid synthesis enzymes. Recent work has begun to uncover how the coordinated signaling of multiple extrinsic factors promotes complexity in dendritic trees and ensures robust dendritic patterning. |
format | Online Article Text |
id | pubmed-7838386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78383862021-01-28 Extrinsic Factors Regulating Dendritic Patterning Lin, Tzu-Yang Chen, Pei-Ju Yu, Hung-Hsiang Hsu, Chao-Ping Lee, Chi-Hon Front Cell Neurosci Neuroscience Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning. Surrounding neurons or supporting cells express adhesion receptors and secreted proteins that respectively, act via direct contact or over short distances to shape, size, and localize dendrites during specific developmental stages. The different ligand-receptor interactions and downstream signaling events appear to direct dendrite morphogenesis by converging on two categorical mechanisms: local cytoskeletal and adhesion modulation and global transcriptional regulation of key dendritic growth components, such as lipid synthesis enzymes. Recent work has begun to uncover how the coordinated signaling of multiple extrinsic factors promotes complexity in dendritic trees and ensures robust dendritic patterning. Frontiers Media S.A. 2021-01-13 /pmc/articles/PMC7838386/ /pubmed/33519386 http://dx.doi.org/10.3389/fncel.2020.622808 Text en Copyright © 2021 Lin, Chen, Yu, Hsu and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lin, Tzu-Yang Chen, Pei-Ju Yu, Hung-Hsiang Hsu, Chao-Ping Lee, Chi-Hon Extrinsic Factors Regulating Dendritic Patterning |
title | Extrinsic Factors Regulating Dendritic Patterning |
title_full | Extrinsic Factors Regulating Dendritic Patterning |
title_fullStr | Extrinsic Factors Regulating Dendritic Patterning |
title_full_unstemmed | Extrinsic Factors Regulating Dendritic Patterning |
title_short | Extrinsic Factors Regulating Dendritic Patterning |
title_sort | extrinsic factors regulating dendritic patterning |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838386/ https://www.ncbi.nlm.nih.gov/pubmed/33519386 http://dx.doi.org/10.3389/fncel.2020.622808 |
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