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Extrinsic Factors Regulating Dendritic Patterning

Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic inte...

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Autores principales: Lin, Tzu-Yang, Chen, Pei-Ju, Yu, Hung-Hsiang, Hsu, Chao-Ping, Lee, Chi-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838386/
https://www.ncbi.nlm.nih.gov/pubmed/33519386
http://dx.doi.org/10.3389/fncel.2020.622808
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author Lin, Tzu-Yang
Chen, Pei-Ju
Yu, Hung-Hsiang
Hsu, Chao-Ping
Lee, Chi-Hon
author_facet Lin, Tzu-Yang
Chen, Pei-Ju
Yu, Hung-Hsiang
Hsu, Chao-Ping
Lee, Chi-Hon
author_sort Lin, Tzu-Yang
collection PubMed
description Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning. Surrounding neurons or supporting cells express adhesion receptors and secreted proteins that respectively, act via direct contact or over short distances to shape, size, and localize dendrites during specific developmental stages. The different ligand-receptor interactions and downstream signaling events appear to direct dendrite morphogenesis by converging on two categorical mechanisms: local cytoskeletal and adhesion modulation and global transcriptional regulation of key dendritic growth components, such as lipid synthesis enzymes. Recent work has begun to uncover how the coordinated signaling of multiple extrinsic factors promotes complexity in dendritic trees and ensures robust dendritic patterning.
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spelling pubmed-78383862021-01-28 Extrinsic Factors Regulating Dendritic Patterning Lin, Tzu-Yang Chen, Pei-Ju Yu, Hung-Hsiang Hsu, Chao-Ping Lee, Chi-Hon Front Cell Neurosci Neuroscience Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning. Surrounding neurons or supporting cells express adhesion receptors and secreted proteins that respectively, act via direct contact or over short distances to shape, size, and localize dendrites during specific developmental stages. The different ligand-receptor interactions and downstream signaling events appear to direct dendrite morphogenesis by converging on two categorical mechanisms: local cytoskeletal and adhesion modulation and global transcriptional regulation of key dendritic growth components, such as lipid synthesis enzymes. Recent work has begun to uncover how the coordinated signaling of multiple extrinsic factors promotes complexity in dendritic trees and ensures robust dendritic patterning. Frontiers Media S.A. 2021-01-13 /pmc/articles/PMC7838386/ /pubmed/33519386 http://dx.doi.org/10.3389/fncel.2020.622808 Text en Copyright © 2021 Lin, Chen, Yu, Hsu and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lin, Tzu-Yang
Chen, Pei-Ju
Yu, Hung-Hsiang
Hsu, Chao-Ping
Lee, Chi-Hon
Extrinsic Factors Regulating Dendritic Patterning
title Extrinsic Factors Regulating Dendritic Patterning
title_full Extrinsic Factors Regulating Dendritic Patterning
title_fullStr Extrinsic Factors Regulating Dendritic Patterning
title_full_unstemmed Extrinsic Factors Regulating Dendritic Patterning
title_short Extrinsic Factors Regulating Dendritic Patterning
title_sort extrinsic factors regulating dendritic patterning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838386/
https://www.ncbi.nlm.nih.gov/pubmed/33519386
http://dx.doi.org/10.3389/fncel.2020.622808
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