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Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit

Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Patients with...

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Autores principales: Daher, Ayham, Balfanz, Paul, Aetou, Maria, Hartmann, Bojan, Müller-Wieland, Dirk, Müller, Tobias, Marx, Nikolaus, Dreher, Michael, Cornelissen, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838409/
https://www.ncbi.nlm.nih.gov/pubmed/33500431
http://dx.doi.org/10.1038/s41598-021-81444-9
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author Daher, Ayham
Balfanz, Paul
Aetou, Maria
Hartmann, Bojan
Müller-Wieland, Dirk
Müller, Tobias
Marx, Nikolaus
Dreher, Michael
Cornelissen, Christian G.
author_facet Daher, Ayham
Balfanz, Paul
Aetou, Maria
Hartmann, Bojan
Müller-Wieland, Dirk
Müller, Tobias
Marx, Nikolaus
Dreher, Michael
Cornelissen, Christian G.
author_sort Daher, Ayham
collection PubMed
description Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Patients without ARDS but in need of supplementary oxygen have received much less attention. This study describes the diagnosis, symptoms, treatment and outcomes of hospitalized patients with COVID-19 needing oxygen support during their stay on regular ward. All 133 patients admitted to the RWTH Aachen university hospital with the diagnosis of COVID-19 were included in an observational registry. Clinical data sets were extracted from the hospital information system. This analysis includes all 57 patients requiring supplemental oxygen not admitted to the ICU. 57 patients needing supplemental oxygen and being treated outside the ICU were analyzed. Patients exhibited the typical set of symptoms for COVID-19. Of note, hypoxic patients mostly did not suffer from clinically relevant dyspnea despite oxygen saturations below 92%. Patients had fever for 7 [2–11] days and needed supplemental oxygen for 8 [5–13] days resulting in an overall hospitalization time of 12 [7–20] days. In addition, patients had persisting systemic inflammation with CRP levels remaining elevated until discharge or death. This description of COVID-19 patients requiring oxygen therapy should be taken into account when planning treatment capacity. Patients on oxygen need long-term inpatient care.
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spelling pubmed-78384092021-01-28 Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit Daher, Ayham Balfanz, Paul Aetou, Maria Hartmann, Bojan Müller-Wieland, Dirk Müller, Tobias Marx, Nikolaus Dreher, Michael Cornelissen, Christian G. Sci Rep Article Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Patients without ARDS but in need of supplementary oxygen have received much less attention. This study describes the diagnosis, symptoms, treatment and outcomes of hospitalized patients with COVID-19 needing oxygen support during their stay on regular ward. All 133 patients admitted to the RWTH Aachen university hospital with the diagnosis of COVID-19 were included in an observational registry. Clinical data sets were extracted from the hospital information system. This analysis includes all 57 patients requiring supplemental oxygen not admitted to the ICU. 57 patients needing supplemental oxygen and being treated outside the ICU were analyzed. Patients exhibited the typical set of symptoms for COVID-19. Of note, hypoxic patients mostly did not suffer from clinically relevant dyspnea despite oxygen saturations below 92%. Patients had fever for 7 [2–11] days and needed supplemental oxygen for 8 [5–13] days resulting in an overall hospitalization time of 12 [7–20] days. In addition, patients had persisting systemic inflammation with CRP levels remaining elevated until discharge or death. This description of COVID-19 patients requiring oxygen therapy should be taken into account when planning treatment capacity. Patients on oxygen need long-term inpatient care. Nature Publishing Group UK 2021-01-26 /pmc/articles/PMC7838409/ /pubmed/33500431 http://dx.doi.org/10.1038/s41598-021-81444-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Daher, Ayham
Balfanz, Paul
Aetou, Maria
Hartmann, Bojan
Müller-Wieland, Dirk
Müller, Tobias
Marx, Nikolaus
Dreher, Michael
Cornelissen, Christian G.
Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_full Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_fullStr Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_full_unstemmed Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_short Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_sort clinical course of covid-19 patients needing supplemental oxygen outside the intensive care unit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838409/
https://www.ncbi.nlm.nih.gov/pubmed/33500431
http://dx.doi.org/10.1038/s41598-021-81444-9
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