AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer

Liver cancer is one of the most lethal cancers, but our knowledge of the molecular mechanism underlying this process remains insufficient. Through deep sequencing and expression regulation analysis in liver cancer cells, we identified two novel factors, AKR1C2 (positive factor) and NF1 (negative fac...

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Detalles Bibliográficos
Autores principales: Li, Cong, Wu, Xia, Zhang, Wei, Li, Jia, Liu, Huawei, Hao, Ming, Wang, Junsong, Zhang, Honghai, Yang, Gengxia, Hao, Meijun, Sheng, Shoupeng, Sun, Yu, Long, Jiang, Hu, Xiongbing, Zhang, Hanshuo, Hu, Caixia, Li, Li, Zheng, Jiasheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838427/
https://www.ncbi.nlm.nih.gov/pubmed/26351209
http://dx.doi.org/10.3727/096504015X14386062091352
Descripción
Sumario:Liver cancer is one of the most lethal cancers, but our knowledge of the molecular mechanism underlying this process remains insufficient. Through deep sequencing and expression regulation analysis in liver cancer cells, we identified two novel factors, AKR1C2 (positive factor) and NF1 (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer. They were experimentally validated to have the capacities of regulating cell migration, cell invasion, cell proliferation, and EMT. Further clinic expression and animal model evidence confirmed their functions. Together, our findings provide a new insight into the pharmaceutical and therapeutic use of AEG-1 and downstream AKR1C2 and NF1.

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