MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer

MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer. The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer. Here we show that miR-181a levels were significantl...

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Autores principales: Lin, Feng, Li, Ye, Yan, Shuai, Liu, Shaoping, Qian, Wenjun, Shen, Dong, Lin, Qingfeng, Mao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838452/
https://www.ncbi.nlm.nih.gov/pubmed/25706394
http://dx.doi.org/10.3727/096504014X14024160459203
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author Lin, Feng
Li, Ye
Yan, Shuai
Liu, Shaoping
Qian, Wenjun
Shen, Dong
Lin, Qingfeng
Mao, Weidong
author_facet Lin, Feng
Li, Ye
Yan, Shuai
Liu, Shaoping
Qian, Wenjun
Shen, Dong
Lin, Qingfeng
Mao, Weidong
author_sort Lin, Feng
collection PubMed
description MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer. The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer. Here we show that miR-181a levels were significantly downregulated in gastric cancer tissues compared with the adjacent normal regions in 80 paired samples. Moreover, the lower levels of miR-181a were associated with the pM or pTNM stage in clinical gastric cancer patients. In addition, the ectopic expression of miR-181a in the gastric cancer cell line HGC-27 inhibited cell proliferation, cell migration, and invasion by directly interacting with the mRNA encoding the oncogenic factor Prox1. Taken together, our results indicate that miR-181a might act as a tumor suppressor in gastric cancer, which may provide a novel diagnostic and therapeutic option for human gastric cancer in the near future.
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spelling pubmed-78384522021-02-16 MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer Lin, Feng Li, Ye Yan, Shuai Liu, Shaoping Qian, Wenjun Shen, Dong Lin, Qingfeng Mao, Weidong Oncol Res Article MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer. The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer. Here we show that miR-181a levels were significantly downregulated in gastric cancer tissues compared with the adjacent normal regions in 80 paired samples. Moreover, the lower levels of miR-181a were associated with the pM or pTNM stage in clinical gastric cancer patients. In addition, the ectopic expression of miR-181a in the gastric cancer cell line HGC-27 inhibited cell proliferation, cell migration, and invasion by directly interacting with the mRNA encoding the oncogenic factor Prox1. Taken together, our results indicate that miR-181a might act as a tumor suppressor in gastric cancer, which may provide a novel diagnostic and therapeutic option for human gastric cancer in the near future. Cognizant Communication Corporation 2015-02-09 /pmc/articles/PMC7838452/ /pubmed/25706394 http://dx.doi.org/10.3727/096504014X14024160459203 Text en Copyright © 2015 Cognizant Comm. Corp. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Lin, Feng
Li, Ye
Yan, Shuai
Liu, Shaoping
Qian, Wenjun
Shen, Dong
Lin, Qingfeng
Mao, Weidong
MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title_full MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title_fullStr MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title_full_unstemmed MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title_short MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer
title_sort microrna-181a inhibits tumor proliferation, invasiveness, and metastasis and is downregulated in gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838452/
https://www.ncbi.nlm.nih.gov/pubmed/25706394
http://dx.doi.org/10.3727/096504014X14024160459203
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