Cargando…
Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19
Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction between SARS-CoV-2 spike protein and its cogna...
Autores principales: | Bojadzic, Damir, Alcazar, Oscar, Buchwald, Peter |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838506/ https://www.ncbi.nlm.nih.gov/pubmed/33519460 http://dx.doi.org/10.3389/fphar.2020.600372 |
Ejemplares similares
-
Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction
por: Bojadzic, Damir, et al.
Publicado: (2018) -
Methylene Blue Is a Nonspecific Protein–Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19
por: Chuang, Sung-Ting, et al.
Publicado: (2022) -
Methylene Blue: Revisited
por: Ginimuge, Prashant R., et al.
Publicado: (2010) -
A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2
por: Tsegay, Kaleb B., et al.
Publicado: (2021) -
Broad-Spectrum Small-Molecule Inhibitors of the SARS-CoV-2 Spike—ACE2 Protein–Protein Interaction from a Chemical Space of Privileged Protein Binders
por: Chuang, Sung-Ting, et al.
Publicado: (2022)