The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be gi...

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Autores principales: Potje, Simone Regina, Paula, Tiago Dal-Cin, Paulo, Michele, Bendhack, Lusiane Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838704/
https://www.ncbi.nlm.nih.gov/pubmed/33519523
http://dx.doi.org/10.3389/fphys.2020.620840
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author Potje, Simone Regina
Paula, Tiago Dal-Cin
Paulo, Michele
Bendhack, Lusiane Maria
author_facet Potje, Simone Regina
Paula, Tiago Dal-Cin
Paulo, Michele
Bendhack, Lusiane Maria
author_sort Potje, Simone Regina
collection PubMed
description This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be given in glycocalyx and caveolae that are associated with impaired production of nitric oxide (NO) and generation of reactive oxygen species (ROS). Such alterations could contribute to the development of cardiovascular diseases, such as atherosclerosis, and hypertension.
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spelling pubmed-78387042021-01-28 The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases Potje, Simone Regina Paula, Tiago Dal-Cin Paulo, Michele Bendhack, Lusiane Maria Front Physiol Physiology This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be given in glycocalyx and caveolae that are associated with impaired production of nitric oxide (NO) and generation of reactive oxygen species (ROS). Such alterations could contribute to the development of cardiovascular diseases, such as atherosclerosis, and hypertension. Frontiers Media S.A. 2021-01-13 /pmc/articles/PMC7838704/ /pubmed/33519523 http://dx.doi.org/10.3389/fphys.2020.620840 Text en Copyright © 2021 Potje, Paula, Paulo and Bendhack. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Potje, Simone Regina
Paula, Tiago Dal-Cin
Paulo, Michele
Bendhack, Lusiane Maria
The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title_full The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title_fullStr The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title_full_unstemmed The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title_short The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases
title_sort role of glycocalyx and caveolae in vascular homeostasis and diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838704/
https://www.ncbi.nlm.nih.gov/pubmed/33519523
http://dx.doi.org/10.3389/fphys.2020.620840
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