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miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in...

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Detalles Bibliográficos
Autores principales: Lou, Ye, Liu, Lei, Zhan, Lihui, Wang, Xuewei, Fan, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838722/
https://www.ncbi.nlm.nih.gov/pubmed/27296949
http://dx.doi.org/10.3727/096504016X14597766487753
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author Lou, Ye
Liu, Lei
Zhan, Lihui
Wang, Xuewei
Fan, Hua
author_facet Lou, Ye
Liu, Lei
Zhan, Lihui
Wang, Xuewei
Fan, Hua
author_sort Lou, Ye
collection PubMed
description Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in B-cell ALL and a driver of cellular proliferation and suppressor of apoptosis. We show that miR-187-5p directly targets the 3′-UTR of DKK2 to mediate these effects. We further determine that inhibition of DKK2 by miR-187-5p in Nalm-6 B cells leads to inappropriate activation of Wnt/β-catenin signaling. Together, these findings reveal that the miR-187-5p–DKK2 pathway regulates Wnt/β-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL.
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spelling pubmed-78387222021-02-16 miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2 Lou, Ye Liu, Lei Zhan, Lihui Wang, Xuewei Fan, Hua Oncol Res Article Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in B-cell ALL and a driver of cellular proliferation and suppressor of apoptosis. We show that miR-187-5p directly targets the 3′-UTR of DKK2 to mediate these effects. We further determine that inhibition of DKK2 by miR-187-5p in Nalm-6 B cells leads to inappropriate activation of Wnt/β-catenin signaling. Together, these findings reveal that the miR-187-5p–DKK2 pathway regulates Wnt/β-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL. Cognizant Communication Corporation 2016-06-07 /pmc/articles/PMC7838722/ /pubmed/27296949 http://dx.doi.org/10.3727/096504016X14597766487753 Text en Copyright © 2016 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Lou, Ye
Liu, Lei
Zhan, Lihui
Wang, Xuewei
Fan, Hua
miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title_full miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title_fullStr miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title_full_unstemmed miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title_short miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
title_sort mir-187-5p regulates cell growth and apoptosis in acute lymphoblastic leukemia via dkk2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838722/
https://www.ncbi.nlm.nih.gov/pubmed/27296949
http://dx.doi.org/10.3727/096504016X14597766487753
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