Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells

In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to control...

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Detalles Bibliográficos
Autores principales: Park, Si Jun, Lee, Bo Ram, Kim, Hyeng-Soo, Ji, Young Rae, Sung, Yong Hun, ShikChoi, Kwang, Park, Hum Dai, Kim, Sung-Hyun, Kim, Myoung Ok, Ryoo, Zae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838735/
https://www.ncbi.nlm.nih.gov/pubmed/26931431
http://dx.doi.org/10.3727/096504015X14496932933539
Descripción
Sumario:In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial–mesenchymal transition (EMT).

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