Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells

In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to control...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Si Jun, Lee, Bo Ram, Kim, Hyeng-Soo, Ji, Young Rae, Sung, Yong Hun, ShikChoi, Kwang, Park, Hum Dai, Kim, Sung-Hyun, Kim, Myoung Ok, Ryoo, Zae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838735/
https://www.ncbi.nlm.nih.gov/pubmed/26931431
http://dx.doi.org/10.3727/096504015X14496932933539
_version_ 1783643248897556480
author Park, Si Jun
Lee, Bo Ram
Kim, Hyeng-Soo
Ji, Young Rae
Sung, Yong Hun
ShikChoi, Kwang
Park, Hum Dai
Kim, Sung-Hyun
Kim, Myoung Ok
Ryoo, Zae Young
author_facet Park, Si Jun
Lee, Bo Ram
Kim, Hyeng-Soo
Ji, Young Rae
Sung, Yong Hun
ShikChoi, Kwang
Park, Hum Dai
Kim, Sung-Hyun
Kim, Myoung Ok
Ryoo, Zae Young
author_sort Park, Si Jun
collection PubMed
description In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial–mesenchymal transition (EMT).
format Online
Article
Text
id pubmed-7838735
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Cognizant Communication Corporation
record_format MEDLINE/PubMed
spelling pubmed-78387352021-02-16 Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells Park, Si Jun Lee, Bo Ram Kim, Hyeng-Soo Ji, Young Rae Sung, Yong Hun ShikChoi, Kwang Park, Hum Dai Kim, Sung-Hyun Kim, Myoung Ok Ryoo, Zae Young Oncol Res Article In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial–mesenchymal transition (EMT). Cognizant Communication Corporation 2016-02-29 /pmc/articles/PMC7838735/ /pubmed/26931431 http://dx.doi.org/10.3727/096504015X14496932933539 Text en Copyright © 2016 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Park, Si Jun
Lee, Bo Ram
Kim, Hyeng-Soo
Ji, Young Rae
Sung, Yong Hun
ShikChoi, Kwang
Park, Hum Dai
Kim, Sung-Hyun
Kim, Myoung Ok
Ryoo, Zae Young
Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title_full Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title_fullStr Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title_full_unstemmed Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title_short Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
title_sort inhibition of migration and invasion by tet-1 overexpression in human lung carcinoma h460 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838735/
https://www.ncbi.nlm.nih.gov/pubmed/26931431
http://dx.doi.org/10.3727/096504015X14496932933539
work_keys_str_mv AT parksijun inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT leeboram inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT kimhyengsoo inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT jiyoungrae inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT sungyonghun inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT shikchoikwang inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT parkhumdai inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT kimsunghyun inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT kimmyoungok inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells
AT ryoozaeyoung inhibitionofmigrationandinvasionbytet1overexpressioninhumanlungcarcinomah460cells

Ejemplares similares