FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion

Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shuang, Zhao, Daqi, Tian, Ruihua, Shi, Hailong, Chen, Xiangming, Liu, Wenzhi, Wei, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838742/
https://www.ncbi.nlm.nih.gov/pubmed/27053348
http://dx.doi.org/10.3727/096504016X14537290676919
Descripción
Sumario:Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that FGF19 is able to enhance migration and invasion abilities of gastric cancer cells. Given its great potency in gastric cancer progression, FGF19 may be an effective target of treatment for advanced gastric cancer patients.

Ejemplares similares