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Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates

Oligonucleotides modified by a 2′-deoxy-2′-(N-methoxyamino) ribonucleotide react readily with aldehydes in slightly acidic conditions to yield the corresponding N-(methoxy)oxazolidine-linked oligonucleotide-conjugates. The reaction is reversible and dynamic in slightly acidic conditions, while the p...

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Detalles Bibliográficos
Autores principales:	Aho, Aapo, Äärelä, Antti, Korhonen, Heidi, Virta, Pasi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838870/ https://www.ncbi.nlm.nih.gov/pubmed/33477693 http://dx.doi.org/10.3390/molecules26020490

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