Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia

We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by Fusarium graminearum, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The e...

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Autores principales: Uscamayta, Mary Gabriela, Martin-Onraet, Alexandra, Espinosa-Bautista, Karla, Herrera-Goepfert, Roberto, Hernández-Castro, Rigoberto, Perez-Jimenez, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838889/
https://www.ncbi.nlm.nih.gov/pubmed/33401374
http://dx.doi.org/10.3390/idr13010002
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author Uscamayta, Mary Gabriela
Martin-Onraet, Alexandra
Espinosa-Bautista, Karla
Herrera-Goepfert, Roberto
Hernández-Castro, Rigoberto
Perez-Jimenez, Carolina
author_facet Uscamayta, Mary Gabriela
Martin-Onraet, Alexandra
Espinosa-Bautista, Karla
Herrera-Goepfert, Roberto
Hernández-Castro, Rigoberto
Perez-Jimenez, Carolina
author_sort Uscamayta, Mary Gabriela
collection PubMed
description We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by Fusarium graminearum, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to Fusarium graminearum.
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spelling pubmed-78388892021-01-28 Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia Uscamayta, Mary Gabriela Martin-Onraet, Alexandra Espinosa-Bautista, Karla Herrera-Goepfert, Roberto Hernández-Castro, Rigoberto Perez-Jimenez, Carolina Infect Dis Rep Case Report We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by Fusarium graminearum, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to Fusarium graminearum. MDPI 2021-01-01 /pmc/articles/PMC7838889/ /pubmed/33401374 http://dx.doi.org/10.3390/idr13010002 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Uscamayta, Mary Gabriela
Martin-Onraet, Alexandra
Espinosa-Bautista, Karla
Herrera-Goepfert, Roberto
Hernández-Castro, Rigoberto
Perez-Jimenez, Carolina
Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title_full Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title_fullStr Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title_full_unstemmed Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title_short Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
title_sort portal dissemination of fusarium graminearum in a patient with acute lymphoblastic leukemia and febrile neutropenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838889/
https://www.ncbi.nlm.nih.gov/pubmed/33401374
http://dx.doi.org/10.3390/idr13010002
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