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Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs
The Drosophila eye displays peculiar sensory organs of unknown function, the mechanosensory bristles, that are intercalated among the adjacent ommatidia. Like the other Drosophila sensory organs, the mechanosensory bristles consist of a bipolar neuron and two tandemly aligned centrioles, the distal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839044/ https://www.ncbi.nlm.nih.gov/pubmed/33466292 http://dx.doi.org/10.3390/jdb9010001 |
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author | Persico, Veronica Callaini, Giuliano Riparbelli, Maria Giovanna |
author_facet | Persico, Veronica Callaini, Giuliano Riparbelli, Maria Giovanna |
author_sort | Persico, Veronica |
collection | PubMed |
description | The Drosophila eye displays peculiar sensory organs of unknown function, the mechanosensory bristles, that are intercalated among the adjacent ommatidia. Like the other Drosophila sensory organs, the mechanosensory bristles consist of a bipolar neuron and two tandemly aligned centrioles, the distal of which nucleates the ciliary axoneme and represents the starting point of the ciliary rootlets. We report here that the centriole associated protein Sas-4 colocalizes with the short ciliary rootlets of the mechanosensory bristles and with the elongated rootlets of chordotonal and olfactory neurons. This finding suggests an unexpected cytoplasmic localization of Sas-4 protein and points to a new underscored role for this protein. Moreover, we observed that the sheath cells associated with the sensory neurons also display two tandemly aligned centrioles but lacks ciliary axonemes, suggesting that the dendrites of the sensory neurons are dispensable for the assembly of aligned centrioles and rootlets. |
format | Online Article Text |
id | pubmed-7839044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78390442021-01-28 Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs Persico, Veronica Callaini, Giuliano Riparbelli, Maria Giovanna J Dev Biol Article The Drosophila eye displays peculiar sensory organs of unknown function, the mechanosensory bristles, that are intercalated among the adjacent ommatidia. Like the other Drosophila sensory organs, the mechanosensory bristles consist of a bipolar neuron and two tandemly aligned centrioles, the distal of which nucleates the ciliary axoneme and represents the starting point of the ciliary rootlets. We report here that the centriole associated protein Sas-4 colocalizes with the short ciliary rootlets of the mechanosensory bristles and with the elongated rootlets of chordotonal and olfactory neurons. This finding suggests an unexpected cytoplasmic localization of Sas-4 protein and points to a new underscored role for this protein. Moreover, we observed that the sheath cells associated with the sensory neurons also display two tandemly aligned centrioles but lacks ciliary axonemes, suggesting that the dendrites of the sensory neurons are dispensable for the assembly of aligned centrioles and rootlets. MDPI 2021-01-05 /pmc/articles/PMC7839044/ /pubmed/33466292 http://dx.doi.org/10.3390/jdb9010001 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Persico, Veronica Callaini, Giuliano Riparbelli, Maria Giovanna Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title | Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title_full | Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title_fullStr | Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title_full_unstemmed | Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title_short | Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs |
title_sort | sas-4 colocalizes with the ciliary rootlets of the drosophila sensory organs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839044/ https://www.ncbi.nlm.nih.gov/pubmed/33466292 http://dx.doi.org/10.3390/jdb9010001 |
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