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From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

During the last decades intermediate filaments (IFs) have emerged as important regulators of cellular signaling events, ascribing IFs with functions beyond the structural support they provide. The organ and developmental stage‐specific expression of IFs regulate cell differentiation within developin...

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Autores principales: Sjöqvist, Marika, Antfolk, Daniel, Suarez‐Rodriguez, Freddy, Sahlgren, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839487/
https://www.ncbi.nlm.nih.gov/pubmed/33205514
http://dx.doi.org/10.1096/fj.202001627R
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author Sjöqvist, Marika
Antfolk, Daniel
Suarez‐Rodriguez, Freddy
Sahlgren, Cecilia
author_facet Sjöqvist, Marika
Antfolk, Daniel
Suarez‐Rodriguez, Freddy
Sahlgren, Cecilia
author_sort Sjöqvist, Marika
collection PubMed
description During the last decades intermediate filaments (IFs) have emerged as important regulators of cellular signaling events, ascribing IFs with functions beyond the structural support they provide. The organ and developmental stage‐specific expression of IFs regulate cell differentiation within developing or remodeling tissues. Lack of IFs causes perturbed stem cell differentiation in vasculature, intestine, nervous system, and mammary gland, in transgenic mouse models. The aberrant cell fate decisions are caused by deregulation of different stem cell signaling pathways, such as Notch, Wnt, YAP/TAZ, and TGFβ. Mutations in genes coding for IFs cause an array of different diseases, many related to stem cell dysfunction, but the molecular mechanisms remain unresolved. Here, we provide a comprehensive overview of how IFs interact with and regulate the activity, localization and function of different signaling proteins in stem cells, and how the assembly state and PTM profile of IFs may affect these processes. Identifying when, where and how IFs and cell signaling congregate, will expand our understanding of IF‐linked stem cell dysfunction during development and disease.
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spelling pubmed-78394872021-02-01 From structural resilience to cell specification — Intermediate filaments as regulators of cell fate Sjöqvist, Marika Antfolk, Daniel Suarez‐Rodriguez, Freddy Sahlgren, Cecilia FASEB J Reviews During the last decades intermediate filaments (IFs) have emerged as important regulators of cellular signaling events, ascribing IFs with functions beyond the structural support they provide. The organ and developmental stage‐specific expression of IFs regulate cell differentiation within developing or remodeling tissues. Lack of IFs causes perturbed stem cell differentiation in vasculature, intestine, nervous system, and mammary gland, in transgenic mouse models. The aberrant cell fate decisions are caused by deregulation of different stem cell signaling pathways, such as Notch, Wnt, YAP/TAZ, and TGFβ. Mutations in genes coding for IFs cause an array of different diseases, many related to stem cell dysfunction, but the molecular mechanisms remain unresolved. Here, we provide a comprehensive overview of how IFs interact with and regulate the activity, localization and function of different signaling proteins in stem cells, and how the assembly state and PTM profile of IFs may affect these processes. Identifying when, where and how IFs and cell signaling congregate, will expand our understanding of IF‐linked stem cell dysfunction during development and disease. John Wiley and Sons Inc. 2020-11-17 2021-01 /pmc/articles/PMC7839487/ /pubmed/33205514 http://dx.doi.org/10.1096/fj.202001627R Text en © 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Sjöqvist, Marika
Antfolk, Daniel
Suarez‐Rodriguez, Freddy
Sahlgren, Cecilia
From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title_full From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title_fullStr From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title_full_unstemmed From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title_short From structural resilience to cell specification — Intermediate filaments as regulators of cell fate
title_sort from structural resilience to cell specification — intermediate filaments as regulators of cell fate
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839487/
https://www.ncbi.nlm.nih.gov/pubmed/33205514
http://dx.doi.org/10.1096/fj.202001627R
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