Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs

Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently shown that a halide methyltransferase (HMT) from Chloracidobacte...

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Detalles Bibliográficos
Autores principales: Tang, Qingyun, Grathwol, Christoph W., Aslan‐Üzel, Aşkın S., Wu, Shuke, Link, Andreas, Pavlidis, Ioannis V., Badenhorst, Christoffel P. S., Bornscheuer, Uwe T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839550/
https://www.ncbi.nlm.nih.gov/pubmed/33108827
http://dx.doi.org/10.1002/anie.202013871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839550/
https://www.ncbi.nlm.nih.gov/pubmed/33108827
http://dx.doi.org/10.1002/anie.202013871

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