Cargando…

Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs

Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently shown that a halide methyltransferase (HMT) from Chloracidobacte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Qingyun, Grathwol, Christoph W., Aslan‐Üzel, Aşkın S., Wu, Shuke, Link, Andreas, Pavlidis, Ioannis V., Badenhorst, Christoffel P. S., Bornscheuer, Uwe T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839550/ https://www.ncbi.nlm.nih.gov/pubmed/33108827 http://dx.doi.org/10.1002/anie.202013871

Ejemplares similares

From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases
por: Tang, Qingyun, et al.
Publicado: (2021)

Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β‐Hydroxylation of Lithocholic Acid
por: Grobe, Sascha, et al.
Publicado: (2020)

An Ultrasensitive Fluorescence Assay for the Detection of Halides and Enzymatic Dehalogenation
por: Aslan‐Üzel, Aşkın S., et al.
Publicado: (2020)

Recent trends in biocatalysis
por: Yi, Dong, et al.
Publicado: (2021)

Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase
por: Bennett, Matthew R., et al.
Publicado: (2018)

Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity
por: Hecko, Sebastian, et al.
Publicado: (2023)

An ADH toolbox for raspberry ketone production from natural resources via a biocatalytic cascade
por: Becker, Aileen, et al.
Publicado: (2021)

Engineering and evaluation of thermostable IsPETase variants for PET degradation
por: Brott, Stefan, et al.
Publicado: (2021)

Biocatalytic Production of Amino Carbohydrates through Oxidoreductase and Transaminase Cascades
por: Aumala, Ville, et al.
Publicado: (2019)

Positioning-Group-Enabled Biocatalytic Oxidative Dearomatization
por: Dockrey, Summer A. Baker, et al.
Publicado: (2019)

Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways
por: Schmermund, Luca, et al.
Publicado: (2021)

Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases
por: Müller, Henrik, et al.
Publicado: (2020)

Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2
por: Balieiro, Alessandra M., et al.
Publicado: (2022)

Zn(2+)-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase
por: Majumdar, Soneya, et al.
Publicado: (2022)

Sequence‐Based Prediction of Promiscuous Acyltransferase Activity in Hydrolases
por: Müller, Henrik, et al.
Publicado: (2020)

A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases
por: Ju, Shuyun, et al.
Publicado: (2023)

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
por: Ahmed-Belkacem, Rostom, et al.
Publicado: (2020)

The conformational changes of Zika virus methyltransferase upon converting SAM to SAH
por: Zhou, Han, et al.
Publicado: (2017)

Crystallographic snapshots of a B(12)-dependent radical SAM methyltransferase
por: Fyfe, Cameron D., et al.
Publicado: (2022)

Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation
por: Mathew, Liju G., et al.
Publicado: (2021)

Biocatalysis: Enzymatic Synthesis for Industrial Applications
por: Wu, Shuke, et al.
Publicado: (2020)

Mechanism-Based Design of Efficient PET Hydrolases
por: Wei, Ren, et al.
Publicado: (2022)

Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems
por: Zhang, Pu, et al.
Publicado: (2022)

A Computational Study of the Promiscuity of the SAM-Dependent Methyltransferase AtHTMT1
por: Lankau, Timm, et al.
Publicado: (2022)

Correction to “Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation”
por: Mathew, Liju G., et al.
Publicado: (2022)

Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls
por: Chen, Jia, et al.
Publicado: (2020)

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
por: Wang, Junlin, et al.
Publicado: (2019)

Asymmetric Biocatalytic Synthesis of 1‐Aryltetrahydro‐β‐carbolines Enabled by “Substrate Walking”
por: Eger, Elisabeth, et al.
Publicado: (2020)

Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
por: Rudenko, A. Yu., et al.
Publicado: (2022)

Hydrogen Peroxide-Based Fluorometric Assay for Real-Time Monitoring of SAM-Dependent Methyltransferases
por: Akhtar, M. Kalim, et al.
Publicado: (2018)

Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases
por: Currie, Mark A., et al.
Publicado: (2017)

Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae
por: Alam, Jahangir, et al.
Publicado: (2021)

S-Adenosylmethionine (SAM)-Dependent Methyltransferase MftM is Responsible for Methylation of the Redox Cofactor Mycofactocin
por: Ellerhorst, Mark, et al.
Publicado: (2022)

Biosensor and chemo-enzymatic one-pot cascade applications to detect and transform PET-derived terephthalic acid in living cells
por: Bayer, Thomas, et al.
Publicado: (2022)

Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted l-aspartic acids
por: Abidin, Mohammad Z., et al.
Publicado: (2021)

Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression
por: Nasibullin, Igor, et al.
Publicado: (2022)

Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles
por: Li, Jun-Kuan, et al.
Publicado: (2022)

Comprehensive Structure–Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations
por: Amatuni, Alexander, et al.
Publicado: (2023)

Recovery of Hydroxytyrosol from Olive Mill Wastewater Using the Promiscuous Hydrolase/Acyltransferase PestE
por: Terholsen, Henrik, et al.
Publicado: (2022)

Inactivation of SAM-Methyltransferase is the Mechanism of Attenuation of a Historic Louse Borne Typhus Vaccine Strain
por: Liu, Yan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hgp9aa50qi2pncl402fmnhe81u