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Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets

2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that...

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Detalles Bibliográficos
Autores principales: Kiraly, Peter, Kern, Nicolas, Plesniak, Mateusz P., Nilsson, Mathias, Procter, David J., Morris, Gareth A., Adams, Ralph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839668/
https://www.ncbi.nlm.nih.gov/pubmed/32965750
http://dx.doi.org/10.1002/anie.202011642
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author Kiraly, Peter
Kern, Nicolas
Plesniak, Mateusz P.
Nilsson, Mathias
Procter, David J.
Morris, Gareth A.
Adams, Ralph W.
author_facet Kiraly, Peter
Kern, Nicolas
Plesniak, Mateusz P.
Nilsson, Mathias
Procter, David J.
Morris, Gareth A.
Adams, Ralph W.
author_sort Kiraly, Peter
collection PubMed
description 2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation and unlock its real potential for many other experiments.
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spelling pubmed-78396682021-02-02 Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets Kiraly, Peter Kern, Nicolas Plesniak, Mateusz P. Nilsson, Mathias Procter, David J. Morris, Gareth A. Adams, Ralph W. Angew Chem Int Ed Engl Communications 2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation and unlock its real potential for many other experiments. John Wiley and Sons Inc. 2020-11-09 2021-01-11 /pmc/articles/PMC7839668/ /pubmed/32965750 http://dx.doi.org/10.1002/anie.202011642 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Kiraly, Peter
Kern, Nicolas
Plesniak, Mateusz P.
Nilsson, Mathias
Procter, David J.
Morris, Gareth A.
Adams, Ralph W.
Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title_full Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title_fullStr Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title_full_unstemmed Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title_short Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
title_sort single‐scan selective excitation of individual nmr signals in overlapping multiplets
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839668/
https://www.ncbi.nlm.nih.gov/pubmed/32965750
http://dx.doi.org/10.1002/anie.202011642
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