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The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood
The Japan Pediatric Helicobacter pylori Study Group published the first guidelines on childhood H. pylori infection in 1997. They were later revised by the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (JSPGHAN). The H. pylori eradication rates, when employing triple ther...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839701/ https://www.ncbi.nlm.nih.gov/pubmed/32657507 http://dx.doi.org/10.1111/ped.14388 |
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author | Kato, Seiichi Shimizu, Toshiaki Toyoda, Shigeru Gold, Benjamin D. Ida, Shinobu Ishige, Takashi Fujimura, Shigeru Kamiya, Shigeru Konno, Mutsuko Kuwabara, Kentaro Ushijima, Kosuke Yoshimura, Norikazu Nakayama, Yoshiko |
author_facet | Kato, Seiichi Shimizu, Toshiaki Toyoda, Shigeru Gold, Benjamin D. Ida, Shinobu Ishige, Takashi Fujimura, Shigeru Kamiya, Shigeru Konno, Mutsuko Kuwabara, Kentaro Ushijima, Kosuke Yoshimura, Norikazu Nakayama, Yoshiko |
author_sort | Kato, Seiichi |
collection | PubMed |
description | The Japan Pediatric Helicobacter pylori Study Group published the first guidelines on childhood H. pylori infection in 1997. They were later revised by the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (JSPGHAN). The H. pylori eradication rates, when employing triple therapy with amoxicillin and clarithromycin, currently recommended as the first‐line therapy of H. pylori infection in Japan, have substantially decreased, creating an important clinical problem worldwide. In Japanese adults, the “test‐and‐treat” strategy for H. pylori infection is under consideration as an approach for gastric cancer prevention. However, the combined North American and European pediatric guidelines have rejected such a strategy for asymptomatic children. As risk for gastric cancer development is high in Japan, determining whether the “test‐and‐treat” strategy can be recommended in children has become an urgent matter. Accordingly, the JSPGHAN has produced a second revision of the H. pylori guidelines, which includes discussion about the issues mentioned above. They consist of 19 clinical questions and 34 statements. An H. pylori culture from gastric biopsies is recommended, not only as a diagnostic test for active infection but for antimicrobial susceptibility testing to optimize eradication therapy. Based upon antimicrobial susceptibility testing of H. pylori strains (especially involving clarithromycin), an eradication regimen including use of the antibiotics to which H. pylori is susceptible is recommended as the first‐line therapy against H. pylori‐associated diseases. The guidelines recommend against a “test‐and‐treat” strategy for H. pylori infection for asymptomatic children to protect against the development of gastric cancer because there has been no evidence supporting this strategy. |
format | Online Article Text |
id | pubmed-7839701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78397012021-02-02 The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood Kato, Seiichi Shimizu, Toshiaki Toyoda, Shigeru Gold, Benjamin D. Ida, Shinobu Ishige, Takashi Fujimura, Shigeru Kamiya, Shigeru Konno, Mutsuko Kuwabara, Kentaro Ushijima, Kosuke Yoshimura, Norikazu Nakayama, Yoshiko Pediatr Int Guidelines The Japan Pediatric Helicobacter pylori Study Group published the first guidelines on childhood H. pylori infection in 1997. They were later revised by the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (JSPGHAN). The H. pylori eradication rates, when employing triple therapy with amoxicillin and clarithromycin, currently recommended as the first‐line therapy of H. pylori infection in Japan, have substantially decreased, creating an important clinical problem worldwide. In Japanese adults, the “test‐and‐treat” strategy for H. pylori infection is under consideration as an approach for gastric cancer prevention. However, the combined North American and European pediatric guidelines have rejected such a strategy for asymptomatic children. As risk for gastric cancer development is high in Japan, determining whether the “test‐and‐treat” strategy can be recommended in children has become an urgent matter. Accordingly, the JSPGHAN has produced a second revision of the H. pylori guidelines, which includes discussion about the issues mentioned above. They consist of 19 clinical questions and 34 statements. An H. pylori culture from gastric biopsies is recommended, not only as a diagnostic test for active infection but for antimicrobial susceptibility testing to optimize eradication therapy. Based upon antimicrobial susceptibility testing of H. pylori strains (especially involving clarithromycin), an eradication regimen including use of the antibiotics to which H. pylori is susceptible is recommended as the first‐line therapy against H. pylori‐associated diseases. The guidelines recommend against a “test‐and‐treat” strategy for H. pylori infection for asymptomatic children to protect against the development of gastric cancer because there has been no evidence supporting this strategy. John Wiley and Sons Inc. 2020-12-22 2020-12 /pmc/articles/PMC7839701/ /pubmed/32657507 http://dx.doi.org/10.1111/ped.14388 Text en © 2020 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Guidelines Kato, Seiichi Shimizu, Toshiaki Toyoda, Shigeru Gold, Benjamin D. Ida, Shinobu Ishige, Takashi Fujimura, Shigeru Kamiya, Shigeru Konno, Mutsuko Kuwabara, Kentaro Ushijima, Kosuke Yoshimura, Norikazu Nakayama, Yoshiko The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title | The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title_full | The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title_fullStr | The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title_full_unstemmed | The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title_short | The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood |
title_sort | updated jspghan guidelines for the management of helicobacter pylori infection in childhood |
topic | Guidelines |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839701/ https://www.ncbi.nlm.nih.gov/pubmed/32657507 http://dx.doi.org/10.1111/ped.14388 |
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