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In‐Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells

We report here the in‐cell NMR‐spectroscopic observation of the binding of the cognate ligand 2′‐deoxyguanosine to the aptamer domain of the bacterial 2′‐deoxyguanosine‐sensing riboswitch in eukaryotic cells, namely Xenopus laevis oocytes and in human HeLa cells. The riboswitch is sufficiently stabl...

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Detalles Bibliográficos
Autores principales:	Broft, P., Dzatko, S., Krafcikova, M., Wacker, A., Hänsel‐Hertsch, Robert, Dötsch, Volker, Trantirek, L., Schwalbe, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839747/ https://www.ncbi.nlm.nih.gov/pubmed/32975353 http://dx.doi.org/10.1002/anie.202007184

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