Cargando…

The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction

The keratin network of intermediate filaments provides keratinocytes with essential mechanical strength and resilience, but the contribution to mechanosensing remains poorly understood. Here, we investigated the role of the keratin cytoskeleton in the response to altered matrix rigidity. We found th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laly, Ana C., Sliogeryte, Kristina, Pundel, Oscar J., Ross, Rosie, Keeling, Michael C., Avisetti, Deepa, Waseem, Ahmad, Gavara, Núria, Connelly, John T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840118/ https://www.ncbi.nlm.nih.gov/pubmed/33571121 http://dx.doi.org/10.1126/sciadv.abd6187

Ejemplares similares

Withaferin-A Can Be Used to Modulate the Keratin Network of Intermediate Filaments in Human Epidermal Keratinocytes
por: Keeling, Michael C., et al.
Publicado: (2020)

A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes
por: Feng, Xia, et al.
Publicado: (2015)

Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development
por: Sanghvi-Shah, Rucha, et al.
Publicado: (2017)

Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration
por: Sliogeryte, Kristina, et al.
Publicado: (2019)

Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour
por: Flores, Luis R., et al.
Publicado: (2019)

Author Correction: Lifeact-TagGFP2 alters F-actin organization, cellular morphology and biophysical behaviour
por: Flores, Luis R., et al.
Publicado: (2019)

Ezrin Phosphorylation at T567 Modulates Cell Migration, Mechanical Properties, and Cytoskeletal Organization
por: Zhang, Xiaoli, et al.
Publicado: (2020)

Model for Bundling of Keratin Intermediate Filaments
por: Haimov, Ehud, et al.
Publicado: (2020)

The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins
por: Aldehlawi, Hebah, et al.
Publicado: (2019)

Structures of the ß-Keratin Filaments and Keratin Intermediate Filaments in the Epidermal Appendages of Birds and Reptiles (Sauropsids)
por: Parry, David A.D.
Publicado: (2021)

The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments
Publicado: (1986)

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia
por: Windoffer, Reinhard, et al.
Publicado: (2011)

The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro
por: Bousquet, Olivier, et al.
Publicado: (2001)

Keratin incorporation into intermediate filament networks is a rapid process
Publicado: (1991)

Self-organization of keratin intermediate filaments into cross-linked networks
por: Lee, Chang-Hun, et al.
Publicado: (2009)

Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro
Publicado: (1990)

Insights into the Dynamic Properties of Keratin Intermediate Filaments in Living Epithelial Cells
por: Yoon, Kyeong Han, et al.
Publicado: (2001)

Self-consistent field theory for the interactions between keratin intermediate filaments
por: Akinshina, Anna, et al.
Publicado: (2013)

Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly
por: Bray, David J., et al.
Publicado: (2015)

Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments
por: Velez-delValle, Cristina, et al.
Publicado: (2016)

Keratin Promotes Differentiation of Keratinocytes Seeded on Collagen/Keratin Hydrogels
por: Zuniga, Kameel, et al.
Publicado: (2022)

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins
Publicado: (1994)

Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis
por: Caulín, Carlos, et al.
Publicado: (1997)

Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin
por: Sharma, Pooja, et al.
Publicado: (2019)

The Intermediate Filament Network in Cultured Human Keratinocytes Is Remarkably Extensible and Resilient
por: Fudge, Douglas, et al.
Publicado: (2008)

Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks
Publicado: (1993)

Assembly of keratin onto PtK1 cytoskeletons: evidence for an intermediate filament organizing center
Publicado: (1982)

Multiple roles for keratin intermediate filaments in the regulation of epithelial barrier function and apico-basal polarity
por: Salas, Pedro J., et al.
Publicado: (2016)

14-3-3 targets keratin intermediate filaments to mechanically sensitive cell–cell contacts
por: Mariani, Richard A., et al.
Publicado: (2020)

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16
Publicado: (1996)

Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes
por: Valencia, Rocio G., et al.
Publicado: (2013)

Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
por: Sliogeryte, Kristina, et al.
Publicado: (2016)

The fibrillar substructure of keratin filaments unraveled
Publicado: (1983)

In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments: A Novel Role for Stabilization by Disulfide Bonding
por: Wang, He, et al.
Publicado: (2000)

Proteins IEF (isoelectric focusing) 31 and IEF 46 are keratin-type components of the intermediate-sized filaments: keratins of various human cultured epithelial cells
Publicado: (1983)

Role of keratin 24 in human epidermal keratinocytes
por: Min, Min, et al.
Publicado: (2017)

Intermediate filaments
por: Steinert, P. M., et al.
Publicado: (1984)

Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments
Publicado: (1989)

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair
por: Wong, Pauline, et al.
Publicado: (2003)

Elucidating the early stages of keratin filament assembly
Publicado: (1990)

Cannot write session to /tmp/vufind_sessions/sess_ic5jkps6p5b50m9m5magsqf078