NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

Ubiquitin protein ligase E3 component N-recognin 7 (UBR7) is the most divergent member of UBR box–containing E3 ubiquitin ligases/recognins that mediate the proteasomal degradation of its substrates through the N-end rule. Here, we used a proteomic approach and found phosphoribosyl pyrophosphate syn...

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Detalles Bibliográficos
Autores principales: Srivastava, Shashank, Sahu, Umakant, Zhou, Yalu, Hogan, Ann K., Sathyan, Kizhakke Mattada, Bodner, Justin, Huang, Jiehuan, Wong, Kelvin A., Khalatyan, Natalia, Savas, Jeffrey N., Ntziachristos, Panagiotis, Ben-Sahra, Issam, Foltz, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840127/
https://www.ncbi.nlm.nih.gov/pubmed/33571115
http://dx.doi.org/10.1126/sciadv.abc9781

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