A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By de...

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Detalles Bibliográficos
Autores principales: Nims, Robert J., Pferdehirt, Lara, Ho, Noelani B., Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K., O’Conor, Christopher J., Liedtke, Wolfgang B., Zhang, Bo, McNulty, Amy L., Guilak, Farshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840132/
https://www.ncbi.nlm.nih.gov/pubmed/33571125
http://dx.doi.org/10.1126/sciadv.abd9858

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