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Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploited, and several mechanistic aspects of their activation and inactivation have remained unclear. Enabled by a new crystallization design, we present five new structures: apo-state NTSR...
Autores principales: | Deluigi, Mattia, Klipp, Alexander, Klenk, Christoph, Merklinger, Lisa, Eberle, Stefanie A., Morstein, Lena, Heine, Philipp, Mittl, Peer R. E., Ernst, Patrick, Kamenecka, Theodore M., He, Yuanjun, Vacca, Santiago, Egloff, Pascal, Honegger, Annemarie, Plückthun, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840143/ https://www.ncbi.nlm.nih.gov/pubmed/33571132 http://dx.doi.org/10.1126/sciadv.abe5504 |
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