Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated dur...

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Detalles Bibliográficos
Autores principales: Angulo, Guillem, Zeleznjak, Jelena, Martínez-Vicente, Pablo, Puñet-Ortiz, Joan, Hengel, Hartmut, Messerle, Martin, Oxenius, Annette, Jonjic, Stipan, Krmpotić, Astrid, Engel, Pablo, Angulo, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840182/
https://www.ncbi.nlm.nih.gov/pubmed/33459589
http://dx.doi.org/10.7554/eLife.59350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840182/
https://www.ncbi.nlm.nih.gov/pubmed/33459589
http://dx.doi.org/10.7554/eLife.59350

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