Cargando…

Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated dur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angulo, Guillem, Zeleznjak, Jelena, Martínez-Vicente, Pablo, Puñet-Ortiz, Joan, Hengel, Hartmut, Messerle, Martin, Oxenius, Annette, Jonjic, Stipan, Krmpotić, Astrid, Engel, Pablo, Angulo, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840182/ https://www.ncbi.nlm.nih.gov/pubmed/33459589 http://dx.doi.org/10.7554/eLife.59350

Ejemplares similares

Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
por: Strazic Geljic, Ivana, et al.
Publicado: (2020)

The Immunoevasive Function Encoded by the Mouse Cytomegalovirus Gene m152 Protects the Virus against T Cell Control in Vivo
por: Krmpotic, Astrid, et al.
Publicado: (1999)

Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
por: Zarama, Angela, et al.
Publicado: (2014)

CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach
por: Šustić, Marko, et al.
Publicado: (2021)

Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
por: Polić, Bojan, et al.
Publicado: (1998)

Manipulation of NKG2D Ligands by Cytomegaloviruses: Impact on Innate and Adaptive Immune Response
por: Slavuljica, Irena, et al.
Publicado: (2011)

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection
por: Popovic, Branka, et al.
Publicado: (2017)

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
por: Krmpotic, Astrid, et al.
Publicado: (2005)

Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells
por: Walton, Senta M., et al.
Publicado: (2011)

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
por: Arapović, Maja, et al.
Publicado: (2016)

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
por: Železnjak, Jelena, et al.
Publicado: (2019)

The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
por: Lenac, Tihana, et al.
Publicado: (2006)

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand
por: Tomić, Adriana, et al.
Publicado: (2016)

Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
por: Pyzik, Michał, et al.
Publicado: (2011)

Murine Cytomegalovirus Infection Induces Susceptibility to EAE in Resistant BALB/c Mice
por: Milovanovic, Jelena, et al.
Publicado: (2017)

Inflammatory monocytes and NK cells play a crucial role in DNAM-1–dependent control of cytomegalovirus infection
por: Lenac Rovis, Tihana, et al.
Publicado: (2016)

Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
por: Babić, Marina, et al.
Publicado: (2010)

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation
por: Kolb, Philipp, et al.
Publicado: (2021)

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
por: Khaleafi, Raghad, et al.
Publicado: (2023)

Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines
por: Hiršl, Lea, et al.
Publicado: (2018)

Memory CD8 T Cells Generated by Cytomegalovirus Vaccine Vector Expressing NKG2D Ligand Have Effector-Like Phenotype and Distinct Functional Features
por: Šustić, Marko, et al.
Publicado: (2021)

NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection
por: Pallmer, Katharina, et al.
Publicado: (2019)

Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family
por: Martínez-Vicente, Pablo, et al.
Publicado: (2020)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands
por: Dölken, Lars, et al.
Publicado: (2010)

Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor
por: Martínez-Vicente, Pablo, et al.
Publicado: (2019)

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
por: Borst, Eva Maria, et al.
Publicado: (2022)

Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
por: Le-Trilling, Vu Thuy Khanh, et al.
Publicado: (2023)

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
por: Rožmanić, Carmen, et al.
Publicado: (2023)

Ly49P recognition of cytomegalovirus-infected cells expressing H2-D(k) and CMV-encoded m04 correlates with the NK cell antiviral response
por: Kielczewska, Agnieszka, et al.
Publicado: (2009)

Cytomegalovirus Infection and Inflammation in Developing Brain
por: Krstanović, Fran, et al.
Publicado: (2021)

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING
por: Piersma, Sytse J, et al.
Publicado: (2020)

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection
por: Rodríguez-Martín, Sara, et al.
Publicado: (2012)

Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System
por: Pupuleku, Aldi, et al.
Publicado: (2017)

Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus
por: Ravlić, Sanda, et al.
Publicado: (2021)

The Role of C-reactive Protein in Patient Risk Stratification and Treatment
por: Arroyo-Espliguero, Ramón, et al.
Publicado: (2021)

Inhibitory IL-10-producing CD4(+) T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1
por: Clement, Mathew, et al.
Publicado: (2023)

Loss of human ICOSL results in combined immunodeficiency
por: Roussel, Lucie, et al.
Publicado: (2018)

Osteopontin binds ICOSL promoting tumor metastasis
por: Raineri, Davide, et al.
Publicado: (2020)

The ICOS–ICOSL pathway tunes thymic selection
por: Dong, Mengqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q7hkqabb8qee3dqsjlfc7llvaf