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The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases

Saffron is commonly used in traditional medicines and precious perfumes. It contains pharmacologically active compounds with notably potent antioxidant activity. Saffron has a variety of active components, including crocin, crocetin, and safranal. Oxidative stress plays an important role in many car...

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Autores principales: Su, Xin, Yuan, Chao, Wang, Li, Chen, Runqi, Li, Xiangying, Zhang, Yijun, Liu, Can, Liu, Xu, Liang, Wanping, Xing, Yanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840270/
https://www.ncbi.nlm.nih.gov/pubmed/33542784
http://dx.doi.org/10.1155/2021/6699821
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author Su, Xin
Yuan, Chao
Wang, Li
Chen, Runqi
Li, Xiangying
Zhang, Yijun
Liu, Can
Liu, Xu
Liang, Wanping
Xing, Yanwei
author_facet Su, Xin
Yuan, Chao
Wang, Li
Chen, Runqi
Li, Xiangying
Zhang, Yijun
Liu, Can
Liu, Xu
Liang, Wanping
Xing, Yanwei
author_sort Su, Xin
collection PubMed
description Saffron is commonly used in traditional medicines and precious perfumes. It contains pharmacologically active compounds with notably potent antioxidant activity. Saffron has a variety of active components, including crocin, crocetin, and safranal. Oxidative stress plays an important role in many cardiovascular diseases, and its uncontrolled chain reaction is related to myocardial injury. Numerous studies have confirmed that saffron exact exhibits protective effects on the myocardium and might be beneficial in the treatment of cardiovascular disease. In view of the role of oxidative stress in cardiovascular disease, people have shown considerable interest in the potential role of saffron extract as a treatment for a range of cardiovascular diseases. This review analyzed the use of saffron in the treatment of cardiovascular diseases through antioxidant stress from four aspects: antiatherosclerosis, antimyocardial ischemia, anti-ischemia reperfusion injury, and improvement in drug-induced cardiotoxicity, particularly anthracycline-induced. Although data is limited in humans with only two clinically relevant studies, the results of preclinical studies regarding the antioxidant stress effects of saffron are promising and warrant further research in clinical trials. This review summarized the protective effect of saffron in cardiovascular diseases and drug-induced cardiotoxicity. It will facilitate pharmacological research and development and promote utilization of saffron.
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spelling pubmed-78402702021-02-03 The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases Su, Xin Yuan, Chao Wang, Li Chen, Runqi Li, Xiangying Zhang, Yijun Liu, Can Liu, Xu Liang, Wanping Xing, Yanwei Oxid Med Cell Longev Review Article Saffron is commonly used in traditional medicines and precious perfumes. It contains pharmacologically active compounds with notably potent antioxidant activity. Saffron has a variety of active components, including crocin, crocetin, and safranal. Oxidative stress plays an important role in many cardiovascular diseases, and its uncontrolled chain reaction is related to myocardial injury. Numerous studies have confirmed that saffron exact exhibits protective effects on the myocardium and might be beneficial in the treatment of cardiovascular disease. In view of the role of oxidative stress in cardiovascular disease, people have shown considerable interest in the potential role of saffron extract as a treatment for a range of cardiovascular diseases. This review analyzed the use of saffron in the treatment of cardiovascular diseases through antioxidant stress from four aspects: antiatherosclerosis, antimyocardial ischemia, anti-ischemia reperfusion injury, and improvement in drug-induced cardiotoxicity, particularly anthracycline-induced. Although data is limited in humans with only two clinically relevant studies, the results of preclinical studies regarding the antioxidant stress effects of saffron are promising and warrant further research in clinical trials. This review summarized the protective effect of saffron in cardiovascular diseases and drug-induced cardiotoxicity. It will facilitate pharmacological research and development and promote utilization of saffron. Hindawi 2021-01-19 /pmc/articles/PMC7840270/ /pubmed/33542784 http://dx.doi.org/10.1155/2021/6699821 Text en Copyright © 2021 Xin Su et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Su, Xin
Yuan, Chao
Wang, Li
Chen, Runqi
Li, Xiangying
Zhang, Yijun
Liu, Can
Liu, Xu
Liang, Wanping
Xing, Yanwei
The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title_full The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title_fullStr The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title_full_unstemmed The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title_short The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases
title_sort beneficial effects of saffron extract on potential oxidative stress in cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840270/
https://www.ncbi.nlm.nih.gov/pubmed/33542784
http://dx.doi.org/10.1155/2021/6699821
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