Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels

Background: Familial nontoxic multinodular goiter (MNG) is a rare disease. One of the associated genes is Kelch-like ECH-associated protein 1 (KEAP1), which encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses. Th...

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Detalles Bibliográficos
Autores principales: Ziros, Panos G., Renaud, Cédric O., Chartoumpekis, Dionysios V., Bongiovanni, Massimo, Habeos, Ioannis G., Liao, Xiao-Hui, Refetoff, Samuel, Kopp, Peter A., Brix, Klaudia, Sykiotis, Gerasimos P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Thyroid Dysfunction: Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840308/
https://www.ncbi.nlm.nih.gov/pubmed/32689903
http://dx.doi.org/10.1089/thy.2020.0044

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